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Literature summary for 2.1.1.41 extracted from

  • Nes, W.D.; Zhou, W.; Ganapathy, K.; Liu, J.; Vatsyayan, R.; Chamala, S.; Hernandez, K.; Miranda, M.
    Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans (2009), Arch. Biochem. Biophys., 481, 210-218.
    View publication on PubMed
Search for more literature for 2.1.1.41

Inhibitors

Inhibitors Comment Organism Structure
(R,S)-24,25-epiminolanosterol
-
 Cryptococcus neoformans
24beta-aminolanosterol
-
 Cryptococcus neoformans
25-aminolanosterol
-
 Cryptococcus neoformans
25-azalanosterol
-
 Cryptococcus neoformans
25-thialanosterol iodide
-
 Cryptococcus neoformans
26-nor-25-thialanosterol
-
 Cryptococcus neoformans
3-aminolanosterol
-
 Cryptococcus neoformans
30-amino-24,25-dihydrolanosterol
-
 Cryptococcus neoformans
7-amino-24,25-dihydrolanosterol
-
 Cryptococcus neoformans
Amphotericin B
-
 Cryptococcus neoformans
itraconazole
-
 Cryptococcus neoformans

Organism

Organism UniProt Comment Textmining
Cryptococcus neoformans
-
-
-
Cryptococcus neoformans 76484
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
14alpha-methylzymosterol + S-adenosyl-L-methionine 37% activity compared to lanosterol Cryptococcus neoformans 14alpha-methyl-24-methylenezymosterol + S-adenosyl-L-homocysteine
-
 ?
14alpha-methylzymosterol + S-adenosyl-L-methionine 37% activity compared to lanosterol Cryptococcus neoformans 76484 14alpha-methyl-24-methylenezymosterol + S-adenosyl-L-homocysteine
-
 ?
31-norlanosterol + S-adenosyl-L-methionine 78% activity compared to lanosterol Cryptococcus neoformans ?
-
 ?
31-norlanosterol + S-adenosyl-L-methionine 78% activity compared to lanosterol Cryptococcus neoformans 76484 ?
-
 ?
4alpha-methylzymosterol + S-adenosyl-L-methionine 43% activity compared to lanosterol Cryptococcus neoformans ?
-
 ?
4alpha-methylzymosterol + S-adenosyl-L-methionine 43% activity compared to lanosterol Cryptococcus neoformans 76484 ?
-
 ?
lanosterol + S-adenosyl-L-methionine 100% activity, lanosterol is the optimal acceptor molecule Cryptococcus neoformans 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
-
 ?
lanosterol + S-adenosyl-L-methionine 100% activity, lanosterol is the optimal acceptor molecule Cryptococcus neoformans 76484 24-methylene-24,25-dihydrolanosterol + S-adenosyl-L-homocysteine
-
 ?
additional information eburicol and obtusifoliol are no substrates Cryptococcus neoformans ?
-
 ?
additional information eburicol and obtusifoliol are no substrates Cryptococcus neoformans 76484 ?
-
 ?
zymosterol + S-adenosyl-L-methionine 61% activity compared to lanosterol Cryptococcus neoformans ?
-
 ?

Synonyms

Synonyms Comment Organism
24-SMT
-
 Cryptococcus neoformans

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Cryptococcus neoformans