Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.4 extracted from

  • Lee, K.; Hwang, O.J.; Reiter, R.J.; Back, K.
    Flavonoids inhibit both rice and sheep serotonin N-acetyltransferases and reduce melatonin levels in plants (2018), J. Pineal Res., 65, e12512 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
fisetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
kaempferol 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
luteolin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
additional information all of the flavonoids tested greatly inhibit the ASMT activity of COMT, and thus the melatonin biosynthetic activity, with the exception of catechin Oryza sativa Japonica Group
morin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
myricetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group
quercetin 0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity Oryza sativa Japonica Group

Organism

Organism UniProt Comment Textmining
Oryza sativa Japonica Group Q6ZD89 cf. EC 2.1.1.42
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Oryza sativa Japonica Group
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + N-acetylserotonin
-
Oryza sativa Japonica Group S-adenosyl-L-homocysteine + melatonin
-
?

General Information

General Information Comment Organism
physiological function rice leaves treated with flavonoids and then cadmium display lower melatonin levels than the flavonoid-untreated control Oryza sativa Japonica Group