Literature summary for 2.1.1.4 extracted from

Ishio, S.; Yamada, H.; Craft, C.M.; Moriyama, Y.
Hydroxyindole-O-methyltransferase is another target for L-glutamate-evoked inhibition of melatonin synthesis in rat pinealocytes (1999), Brain Res., 850, 73-78.

Inhibitors

Inhibitors	Comment	Organism	Structure
L-glutamate	inhibition is reversible, dose-dependent, no inhibition of mRNA expression	Rattus norvegicus
additional information	not inhibitory: (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine	Rattus norvegicus

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue	Comment	Organism	Textmining
pineal gland	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)