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Literature summary for 2.1.1.379 extracted from

  • Lyu, Z.; Shao, N.; Chou, C.W.; Shi, H.; Patel, R.; Duin, E.C.; Whitman, W.B.
    Posttranslational methylation of arginine in methyl coenzyme M reductase has a profound impact on both methanogenesis and growth of Methanococcus maripaludis (2020), J. Bacteriol., 202, e00654-19 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.379

Protein Variants

Protein Variants Comment Organism
G140A/G144A/G146A the mutant sustains a 15.8% loss in Arg275 methylation as compared to the wild type enzyme Methanococcus maripaludis
H375F the mutant sustains a 0.5% loss in Arg275 methylation as compared to the wild type enzyme Methanococcus maripaludis
H375F/DELTAN371 the mutant sustains a 42.5% loss in Arg275 methylation as compared to the wild type enzyme Methanococcus maripaludis
H375G the mutant sustains a 0.8% loss in Arg275 methylation as compared to the wild type enzyme Methanococcus maripaludis
N212A/D213A the mutant sustains a 35% loss in Arg275 methylation as compared to the wild type enzyme Methanococcus maripaludis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + [methyl coenzyme-M reductase subunit McrA]-L-arginine275 + reduced acceptor Methanococcus maripaludis
-
 S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + [methyl coenzyme-M reductase subunit McrA]-(5S)-C-methyl-L-arginine275 + acceptor
-
 ?

Organism

Organism UniProt Comment Textmining
Methanococcus maripaludis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + [methyl coenzyme-M reductase subunit McrA]-L-arginine275 + reduced acceptor
-
 Methanococcus maripaludis S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + [methyl coenzyme-M reductase subunit McrA]-(5S)-C-methyl-L-arginine275 + acceptor
-
 ?

Synonyms

Synonyms Comment Organism
methanogenesis marker protein 10
-
 Methanococcus maripaludis
MMP10
-
 Methanococcus maripaludis
mmpX
-
 Methanococcus maripaludis

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine dependent on Methanococcus maripaludis

General Information

General Information Comment Organism
metabolism the enzyme plays an important role in methanogenesis Methanococcus maripaludis