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Literature summary for 2.1.1.37 extracted from

  • Kasai, Y.; Sato, K.; Utsumi, S.; Ichikawa, S.
    Improvement of SNAr reaction rate by an electron-withdrawing group in the crosslinking of DNA cytosine-5 methyltransferase by a covalent oligodeoxyribonucleotide inhibitor (2018), ChemBioChem, 19, 1866-1872 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information synthesis of 2-amino-3-cyano-4-halopyridine-C-nucleosides (dXPCN) and oligodeoxyribonucleotides containing dXPCN, as inhibitors of DNMT. Oligodeoxyribonucleotides have a cyano group as an electron-withdrawing group at the C3 position of the pyridine ring. Oligodeoxyribonucleotides containing dXPCN effectively form a complex with DNMTs and exhibit cell antiproliferation activity against human cancer cells Haemophilus parahaemolyticus

Organism

Organism UniProt Comment Textmining
Haemophilus parahaemolyticus P05102
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