Literature summary for 2.1.1.37 extracted from

Cavalieri Gomes, C.; da Silveira e Oliveira, C.; Santos Pimenta, L.G.; De Marco, L.; Santiago Gomez, R.
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms (2009), Pathobiology, 76, 136-140.

Search for more literature for 2.1.1.37

Cloned(Commentary)

Cloned (Comment)	Organism
DNMT1 and DNMT3a, expression analysis of the isozymes in salivary gland neoplasmata	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	DNMT1	Homo sapiens	5737	-
nucleus	DNMT1 and DNMT3a	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozymes DNMT1 and DNMT3a	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	DNMTs are overexpressed in tumorigenic cell lines and in a few types of human neoplasms	Homo sapiens	-
salivary gland	immunohistochemical analysis	Homo sapiens	-
salivary gland cancer cell	pleomorphic adenoma, adenoid cystic carcinoma, mucoepidermoid carcinoma and polymorphous low-grade adenocarcinoma of lower lip, buccal mucosa, mandible, tongue, floor, or palate. Positive nuclear and cytoplasmic labeling for DNMT1 occurs in all samples, positive nuclear labeling for DNMT3a occurs only in few neoplasms: 1 pleomorphic adenoma, 2 adenoid cystic carcinoma and 1 mucoepidermoid cases, immunohistochemical	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Dnmt1	-	Homo sapiens
Dnmt3a	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	while DNMT3a is mostly involved in de novo methylation, DNMT1 acts as a maintenance methyltransferase	Homo sapiens

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Release 2023.1 (January 2023)