Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.37 extracted from

  • Phalke, S.; Nickel, O.; Walluscheck, D.; Hortig, F.; Onorati, M.C.; Reuter, G.
    Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2 (2009), Nat. Genet., 41, 696-702.
    View publication on PubMed
Search for more literature for 2.1.1.37

Cloned(Commentary)

Cloned (Comment) Organism
DNMT2 controls retrotransposon silencing and 2R and 3R telomere integrity in somatic cells, overview Drosophila melanogaster

Protein Variants

Protein Variants Comment Organism
additional information generation of a series of null mutations by remobilization of the EP(2)GE15695 element inserted 108 bp upstream of the Dnmt2 gene. EP(2)GE15695 does not affect the Dnmt2 gene. Dnmt2 null strains show stable loss of the subtelomeric clusters of defective Invader4 elements, phenotype, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Drosophila melanogaster
-
 DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo early embryogenesis Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
 Drosophila melanogaster DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
 ?

Synonyms

Synonyms Comment Organism
cytosine-5 methyltransferase
-
 Drosophila melanogaster
Dnmt2
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function DNMT2 controls retrotransposon silencing and telomere integrity in somatic cells, significant DNMT2-dependent DNA methylation occurs during early embryogenesis, overview Drosophila melanogaster