Literature summary for 2.1.1.37 extracted from

Lodde, V.; Modina, S.C.; Franciosi, F.; Zuccari, E.; Tessaro, I.; Luciano, A.M.
Localization of DNA methyltransferase-1 during oocyte differentiation, in vitro maturation and early embryonic development in cow (2009), Eur. J. Histochem., 53, 199-208.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression analysis by RT-PCR	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos	Bos taurus	5737	-
nucleus	during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos	Bos taurus	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
DNA + S-adenosyl-L-methionine	Bos taurus	-	DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	Q24K09	female cows	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	immunohistochemic analysis	Bos taurus	-
oocyte	during differentiation, Dnmt1 is retained in the cytoplasm in metaphase II stage oocytes and zygotes but enters the nuclei of 8-16 cell stage embryos	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
DNA + S-adenosyl-L-methionine	-	Bos taurus	DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine	-	?

Synonyms

Synonyms	Comment	Organism
DNA methyltransferase-1	-	Bos taurus
Dnmt1	-	Bos taurus

Cofactor

Cofactor	Comment	Organism	Structure
S-adenosyl-L-methionine	-	Bos taurus

General Information

General Information	Comment	Organism
physiological function	Dnmt1 is involved in DNA methylation pattern regulation during the late stage oocyte differentiation, maturation and early embryonic development, overview	Bos taurus

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Release 2023.1 (January 2023)