Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.37 extracted from

  • Svedruzic, Z.M.
    Mammalian cytosine DNA methyltransferase Dnmt1: enzymatic mechanism, novel mechanism-based inhibitors, and RNA-directed DNA methylation (2008), Curr. Med. Chem., 15, 92-106.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-pyrimidinone forms a part of inhibitor 1,2-dihydropyrimidin-2-one-5-methylene-(methylsulfonium)-adenosyl, bindng structure and mechanism, overview Homo sapiens
5-aza-cytosine
-
Homo sapiens
5-fluorocytosine
-
Homo sapiens
[1,2-dihydropyrimidin-2-one]-5-methylene-(methylsulfonium)-adenosyl with 2-pyrimidinone ring Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Michaelis-Menten kinetics, Dnmt1 allosteric regulation mechanism, modelling, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Homo sapiens
-
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P26358
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine catalytic reaction mechanism of Dnmt1, allosteric regulation with fast equilibrium, and substrate specificity. Base-flipping and base-stacking are the key mechanism in control of enzymatic activity, detailed overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
DNA + S-adenosyl-L-methionine Dnmt1 methylates DNA at CG sites. Substrate binding and involved motifs in Dnmt1, overview Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?
additional information no activity with single-stranded DNA with one Cm5 site, double-stranded fully methylated DNA, and poly(dA)-poly(T), pol(G), poly(dC)-poly(dG) or poly(dA-dT) Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More Dnmt1 has a small catalytid C-terminal domain and a large regulatory domain at the N-terminal, the two domains are linked by 12 Gly-Lys repeats, structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
cytosine carbon 5 DNA methyltransferase
-
Homo sapiens
cytosine DNA methyltransferase
-
Homo sapiens
Dnmt1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition by mechanism-based inhibitors and kinetics, detailed overview Homo sapiens