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Literature summary for 2.1.1.37 extracted from

  • Kuck, D.; Singh, N.; Lyko, F.; Medina-Franco, J.L.
    Novel and selective DNA methyltransferase inhibitors: docking-based virtual screening and experimental evaluation (2009), Bioorg. Med. Chem., 18, 822-829.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NSC 319745 activation of Dnmt3b Homo sapiens
NSC 345763 slight activation of Dnmt1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
curcumin
-
Homo sapiens
hydralazine inhibition of Dnmt1 Homo sapiens
additional information no inhibition of Dnmt3b by NSC 56071, NSC 348926, NSC 106084, NSC 622444, NSC 408488, NSC 137546, NSC 345763, NSC 54162, NSC 154957, NSC 158324, NSC 57893, and NSC 138419; virtual inhibitor screeening, molecular modeling with Dnmt1, overview. No inhibition of Dnmt1 by NSC 345763, NSC 154957, and NSC 158324 Homo sapiens
NSC 106084 inhibition of Dnmt1 Homo sapiens
NSC 137546 inhibition of Dnmt1 Homo sapiens
NSC 138419 inhibition of Dnmt1 Homo sapiens
NSC 14778 inhibition of Dnmt1; inhibition of Dnmt3b Homo sapiens
NSC 158324 inhibition of Dnmt1 Homo sapiens
NSC 319745 inhibition of Dnmt1 Homo sapiens
NSC 348926 slight inhibition of Dnmt1 Homo sapiens
NSC 408488 inhibition of Dnmt1 Homo sapiens
NSC 54162 inhibition of Dnmt1 Homo sapiens
NSC 56071 inhibition of Dnmt1 Homo sapiens
NSC 57893 inhibition of Dnmt1 Homo sapiens
NSC 622444 inhibition of Dnmt1 Homo sapiens
RG108 slight inhibition of Dnmt1 Homo sapiens
S-adenosyl-L-homocysteine product inhibition of Dnmt1; product inhibition of Dnmt3b Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA + S-adenosyl-L-methionine Homo sapiens
-
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isozyme Dnmt1
-
Homo sapiens
-
isozyme Dnmt3b
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + S-adenosyl-L-methionine
-
Homo sapiens DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
?

Subunits

Subunits Comment Organism
More Dnmt1 molecular modeling, overview Homo sapiens

Synonyms

Synonyms Comment Organism
Dnmt1
-
Homo sapiens
DNMT3B
-
Homo sapiens
DNMTB
-
Homo sapiens
More the enzyme belongs to the DNA methyltransferase, DNMT, enzyme family Homo sapiens

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.017
-
isozyme Dnmt3b Homo sapiens NSC 14778
0.092
-
isozyme Dnmt1 Homo sapiens NSC 14778