Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NSC 319745 | activation of Dnmt3b | Homo sapiens | |
NSC 345763 | slight activation of Dnmt1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | - |
Homo sapiens | |
hydralazine | inhibition of Dnmt1 | Homo sapiens | |
additional information | no inhibition of Dnmt3b by NSC 56071, NSC 348926, NSC 106084, NSC 622444, NSC 408488, NSC 137546, NSC 345763, NSC 54162, NSC 154957, NSC 158324, NSC 57893, and NSC 138419; virtual inhibitor screeening, molecular modeling with Dnmt1, overview. No inhibition of Dnmt1 by NSC 345763, NSC 154957, and NSC 158324 | Homo sapiens | |
NSC 106084 | inhibition of Dnmt1 | Homo sapiens | |
NSC 137546 | inhibition of Dnmt1 | Homo sapiens | |
NSC 138419 | inhibition of Dnmt1 | Homo sapiens | |
NSC 14778 | inhibition of Dnmt1; inhibition of Dnmt3b | Homo sapiens | |
NSC 158324 | inhibition of Dnmt1 | Homo sapiens | |
NSC 319745 | inhibition of Dnmt1 | Homo sapiens | |
NSC 348926 | slight inhibition of Dnmt1 | Homo sapiens | |
NSC 408488 | inhibition of Dnmt1 | Homo sapiens | |
NSC 54162 | inhibition of Dnmt1 | Homo sapiens | |
NSC 56071 | inhibition of Dnmt1 | Homo sapiens | |
NSC 57893 | inhibition of Dnmt1 | Homo sapiens | |
NSC 622444 | inhibition of Dnmt1 | Homo sapiens | |
RG108 | slight inhibition of Dnmt1 | Homo sapiens | |
S-adenosyl-L-homocysteine | product inhibition of Dnmt1; product inhibition of Dnmt3b | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Homo sapiens | - |
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme Dnmt1 | - |
Homo sapiens | - |
isozyme Dnmt3b | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | - |
Homo sapiens | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | Dnmt1 molecular modeling, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Dnmt1 | - |
Homo sapiens |
DNMT3B | - |
Homo sapiens |
DNMTB | - |
Homo sapiens |
More | the enzyme belongs to the DNA methyltransferase, DNMT, enzyme family | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.017 | - |
isozyme Dnmt3b | Homo sapiens | NSC 14778 | |
0.092 | - |
isozyme Dnmt1 | Homo sapiens | NSC 14778 |