Cloned (Comment) | Organism |
---|---|
expressed in High Five insect cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | - |
Homo sapiens | |
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | - |
Homo sapiens | |
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | - |
Homo sapiens | |
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | - |
Homo sapiens | |
2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | - |
Homo sapiens | |
2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid | - |
Homo sapiens | |
additional information | not inhibited by 0.045 mM 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | Homo sapiens | |
S-(1-deazaadenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(3-deazaadenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(8-azaadenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-(2-biphenyl-4-ylethyl)-2-chloroadenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-(2-biphenyl-4-ylethyl)adenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-(3,5-dimethoxybenzyl)adenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-(pyridin-4-ylmethyl)adenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-benzyladenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-phenyladenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-phenylethyladenosyl)-L-homocysteine | - |
Homo sapiens | |
S-(N-phenylpropyladenosyl)-L-homocysteine | - |
Homo sapiens | |
S-adenosyl-L-homocysteine | - |
Homo sapiens | |
S-inosinylhomocysteine | - |
Homo sapiens | |
S-nebularinehomocysteine | - |
Homo sapiens | |
S-Tubercidinylhomocysteine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | Homo sapiens | the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5'-position of the cytosine ring of the DNA | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + DNA | Homo sapiens | the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5 position of the cytosine ring of the DNA | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P26358 | - |
- |
Homo sapiens | Q9UBC3 | - |
- |
Purification (Comment) | Organism |
---|---|
Hitrap SP-Sepharose column chromatography | Homo sapiens |
Q-Sepharose column chromatography and Hitrap heparin column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + DNA | the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5'-position of the cytosine ring of the DNA | Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? | |
S-adenosyl-L-methionine + DNA | the enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine onto the 5 position of the cytosine ring of the DNA | Homo sapiens | S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA methyltransferase | - |
Homo sapiens |
DNMT | - |
Homo sapiens |
Dnmt1 | isoform | Homo sapiens |
DNMT3b2 | isoform | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0003 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-adenosyl-L-homocysteine | |
0.0003 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-Tubercidinylhomocysteine | |
0.0006 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenylpropyladenosyl)-L-homocysteine | |
0.0006 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(2-biphenyl-4-ylethyl)adenosyl)-L-homocysteine | |
0.0009 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(3,5-dimethoxybenzyl)adenosyl)-L-homocysteine | |
0.001 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.001 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-benzyladenosyl)-L-homocysteine | |
0.0015 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-Tubercidinylhomocysteine | |
0.002 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-adenosyl-L-homocysteine | |
0.002 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenyladenosyl)-L-homocysteine | |
0.002 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenylethyladenosyl)-L-homocysteine | |
0.0025 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.0029 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.003 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(8-azaadenosyl)-L-homocysteine | |
0.0036 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(pyridin-4-ylmethyl)adenosyl)-L-homocysteine | |
0.0054 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(2-biphenyl-4-ylethyl)adenosyl)-L-homocysteine | |
0.006 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methyl-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.0067 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(2-biphenyl-4-ylethyl)-2-chloroadenosyl)-L-homocysteine | |
0.0068 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(3-deazaadenosyl)-L-homocysteine | |
0.0068 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-fluoro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.0074 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenylpropyladenosyl)-L-homocysteine | |
0.008 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 8-aza-S-adenosyl-L-homocysteine | |
0.018 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(3,5-dimethoxybenzyl)adenosyl)-L-homocysteine | |
0.021 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.022 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(pyridin-4-ylmethyl)adenosyl)-L-homocysteine | |
0.027 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenylethyladenosyl)-L-homocysteine | |
0.028 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-nebularinehomocysteine | |
0.029 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-(2-biphenyl-4-ylethyl)-2-chloroadenosyl)-L-homocysteine | |
0.045 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 3-deaza-S-adenosyl-L-homocysteine | |
0.045 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 1-deaza-S-adenosyl-L-homocysteine | |
0.045 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(1-deazaadenosyl)-L-homocysteine | |
0.0572 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-chloro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.061 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-benzyladenosyl)-L-homocysteine | |
0.075 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-methoxy-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.154 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-(N-phenyladenosyl)-L-homocysteine | |
0.216 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid | |
0.256 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-([[(2S,3S,4R,5R)-5-(6-amino-2-iodo-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl]sulfanyl)butanoic acid | |
0.3 | - |
isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-nebularinehomocysteine | |
0.5 | - |
isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | 2-amino-4-[([(2S,3S,4R,5R)-5-[6-amino-2-(methylsulfanyl)-9H-purin-9-yl]-3,4-dihydroxytetrahydrofuran-2-yl]methyl)sulfanyl]butanoic acid | |
1 | - |
IC50 above 1 mM, isoform DNMT1, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-inosinylhomocysteine | |
1 | - |
IC50 above 1 mM, isoform DNMT3b2, in 50 mM Tris-HCl pH 7.6, 5% (v/v) glycerol, 1 mM EDTA, 0.1 mg/ml bovine serum albumin, 1 mM dithiothreitol, at 37°C | Homo sapiens | S-inosinylhomocysteine |