Cloned (Comment) | Organism |
---|---|
overexpression of Dnmt3a and Dnmt3b | Drosophila melanogaster |
Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme overexpression does not cause an altered phenotype | Drosophila melanogaster |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Drosophila melanogaster | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | Drosophila melanogaster | the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
isozymes Dnmt3a and Dnmt3b | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
germ cell | male | Drosophila melanogaster | - |
spermatid | - |
Drosophila melanogaster | - |
spermatocyte | primary | Drosophila melanogaster | - |
testis | - |
Drosophila melanogaster | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA + S-adenosyl-L-methionine | the enzyme has distinct target sequences but no preferred methylation sites of promoters or other regulatory elements | Drosophila melanogaster | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? | |
DNA + S-adenosyl-L-methionine | substrate is genomic DNA of Drosophila melanogaster | Drosophila melanogaster | DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA (cytosine-5)-methyltransferase 3A | - |
Drosophila melanogaster |
DNA (cytosine-5)-methyltransferase 3B | - |
Drosophila melanogaster |
Dnmt3a | - |
Drosophila melanogaster |
DNMT3B | - |
Drosophila melanogaster |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Drosophila melanogaster |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Drosophila melanogaster |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Drosophila melanogaster |
General Information | Comment | Organism |
---|---|---|
physiological function | the DNA methylation by the enzyme has no regulatory function for gene expression in Drosophile melnogaster | Drosophila melanogaster |