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Literature summary for 2.1.1.37 extracted from

  • Bacolla, A.; Pradhan, S.; Larson, J.E.; Roberts, R.J.; Wells, R.D.
    Recombinant human DNA (cytosine-5) methyltransferase: III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG*CCG sequence (2001), J. Biol. Chem., 276, 18605-18613.
    View publication on PubMed
Search for more literature for 2.1.1.37

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.0001
-
 (CGG*CCG)73
-
 Homo sapiens
0.0007
-
 poly(dI-dC)*poly(dI-dC)
-
 Homo sapiens
0.0008
-
 (CGG*CCG)12
-
 Homo sapiens
0.003
-
 relaxed circular pRW 3602 DNA containing cytosine
-
 Homo sapiens
0.004
-
 S-adenosyl-L-methionine reaction with (CGG‘CCG)12 Homo sapiens
0.006
-
 S-adenosyl-L-methionine reaction with relaxed circular pRW3602 Homo sapiens
0.007
-
 S-adenosyl-L-methionine reaction with linear pRW3602 Homo sapiens
0.009
-
 S-adenosyl-L-methionine reaction with poly(dI-dC)*poly(dI-dC) Homo sapiens
0.011
-
 S-adenosyl-L-methionine reaction with pRW3602, supercoiled Homo sapiens
0.014
-
 S-adenosyl-L-methionine reaction with (CGG*CCG)73 Homo sapiens
0.02
-
 linear pRW 3602 DNA containing cytosine
-
 Homo sapiens
0.023
-
 supercoiled pRW 3602 DNA containing cytosine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P26358
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine sequential mechanism Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role of the enzyme in maintaining the methylation patterns throughout development, the enzyme may be involved in the etiology of fragile X, a syndrome characterized by de novo methylation of a greatly expanded CGG-CCG triplet repeat sequence Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + (CGG*CCG)12
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + (CGG*CCG)73
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + (CGG*CGG)12
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + DNA
-
 Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + DNA DNA topology strongly influences the reaction rate, which increases with increasing negative superhelical tension Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + linear pRW 3602 DNA containing cytosine
-
 Homo sapiens S-adenosyl-L-homocysteine + linear pRW 3602 DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + poly(dI-dC)*poly(dI-dC)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + poly-(dI-dC)*poly(dI-dC)
-
 Homo sapiens ?
-
 ?
S-adenosyl-L-methionine + relaxed circular pRW 3602 DNA containing cytosine
-
 Homo sapiens S-adenosyl-L-homocysteine + relaxed circular pRW 3602 DNA containing 5-methylcytosine
-
 ?
S-adenosyl-L-methionine + supercoiled pRW 3602 DNA containing cytosine
-
 Homo sapiens S-adenosyl-L-homocysteine + supercoiled pRW 3602 DNA containing 5-methylcytosine
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens
0.00055
-
 (CGG*CCG)73
-
 Homo sapiens
0.00055
-
 relaxed circular pRW 3602 DNA containing cytosine
-
 Homo sapiens
0.00167
-
 linear pRW 3602 DNA containing cytosine
-
 Homo sapiens
0.00278
-
 supercoiled pRW 3602 DNA containing cytosine
-
 Homo sapiens
0.00305
-
 (CGG*CGG)12
-
 Homo sapiens
0.145
-
 poly(dI-dC)*poly(dI-dC)
-
 Homo sapiens