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Literature summary for 2.1.1.355 extracted from

  • Wang, L.; Liu, J.; Li, X.; Lyu, X.; Liu, Z.; Zhao, H.; Jiao, X.; Zhang, W.; Xie, J.; Liu, W.
    A histone H3K9 methyltransferase Dim5 mediates repression of sorbicillinoid biosynthesis in Trichoderma reesei (2022), Microb. Biotechnol., 15, 2533-2546.
    View publication on PubMed
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Organism

Organism UniProt Comment Textmining
Trichoderma reesei G0RU80
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Trichoderma reesei QM6a G0RU80
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Synonyms

Synonyms Comment Organism
Dim5
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 Trichoderma reesei
histone H3K9 methyltransferase
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 Trichoderma reesei
Trire2_111216
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 Trichoderma reesei

General Information

General Information Comment Organism
evolution protein BLAST analyses shows that Dim5 orthologues are widely distributed amongst filamentous Trichoderma, Penicillium, Fusarium, Neurospora and Aspergillus species, although they exhibit different amino acid lengths. To analyse the phylogenetic relationship between Dim5 homologues from filamentous fungi and SpClr4, a phylogenetic tree is built using Dim5 orthologues from this species as well as SpClr4. Filamentous fungi Dim5 orthologues form two distinct clusters from SpClr4. Amongst them, Trichoderma Dim5 shows a close evolutionary relationship with the orthologues from Fusarium and Neurospora species Trichoderma reesei
malfunction TrDIM5 deletion causes an impaired vegetative growth as well as conidiation, whereas the DELTATrdim5 strain displays a remarkable increase in sorbicillinoid production. Post TrDIM5 deletion, the transcription of sorbicillinoid biosynthesis-related genes is significantly upregulated with a more open chromatin structure Trichoderma reesei
physiological function TrDim5 facilitates vegetative growth and conidiation of Trichoderma reesei Trichoderma reesei