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Literature summary for 2.1.1.355 extracted from

  • Weirich, S.; Khella, M.S.; Jeltsch, A.
    Structure, activity and function of the Suv39h1 and Suv39h2 protein lysine methyltransferases (2021), Life, 11, 703.
    View publication on PubMed
Search for more literature for 2.1.1.355

General Stability

General Stability Organism
SUV39H2 is degraded through the ubiquitin-proteasomal pathway and its half-life was reduced by interaction with the translationally controlled tumor protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 Homo sapiens the enzyme introduce H3K9me3 at pericentric heterochromatin S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 Homo sapiens the enzyme introduce H3K9me3 at pericentric heterochromatin S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O43463
-
-
Homo sapiens Q9H5I1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Homo sapiens
-
amygdala
-
 Homo sapiens
-
basal ganglion
-
 Homo sapiens
-
cardiac muscle low expression Homo sapiens
-
cerebellar cortex
-
 Homo sapiens
-
cerebellum very high expression Homo sapiens
-
cerebellum
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
corpus callosum low expression Homo sapiens
-
corpus callosum
-
 Homo sapiens
-
epididymis
-
 Homo sapiens
-
esophagus
-
 Homo sapiens
-
gall bladder low expression Homo sapiens
-
gall bladder
-
 Homo sapiens
-
hypophysis
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver low expression Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
lymph node
-
 Homo sapiens
-
lymph node high expression Homo sapiens
-
midbrain
-
 Homo sapiens
-
ovary
-
 Homo sapiens
-
pancreas low expression Homo sapiens
-
pectoral muscle low expression Homo sapiens
-
pectoral muscle
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
prostate gland
-
 Homo sapiens
-
retina
-
 Homo sapiens
-
salivary gland low expression Homo sapiens
-
seminal vesicle
-
 Homo sapiens
-
seminal vesicle low expression Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-
small intestine
-
 Homo sapiens
-
smooth muscle
-
 Homo sapiens
-
spleen
-
 Homo sapiens
-
spleen high expression Homo sapiens
-
testis high expression Homo sapiens
-
testis
-
 Homo sapiens
-
thymus high expressiond Homo sapiens
-
thymus very high expression Homo sapiens
-
thyroid gland
-
 Homo sapiens
-
tongue
-
 Homo sapiens
-
tonsil
-
 Homo sapiens
-
tonsil high expression Homo sapiens
-
urinary bladder
-
 Homo sapiens
-
uterine cervix
-
 Homo sapiens
-
uterine endometrium
-
 Homo sapiens
-
vagina low activity Homo sapiens
-
vas deferens
-
 Homo sapiens
-
vermiform appendix
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information SUV39H2 also trimethylates LSD1 at K322. SUV39H2 also methylates K134 of H2AX Homo sapiens ?
-
-
additional information other non-histone substrates of SUV39H1 also have chromatin associated roles: methylation of RAG2 by SUV39H1 occurs within its NLS and it alter its sub-nuclear localization. SUV39H1 can also methylate DOT1L. Homo sapiens ?
-
-
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 the enzyme introduce H3K9me3 at pericentric heterochromatin Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 the enzyme introduce H3K9me3 at pericentric heterochromatin Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
SUV39H1
-
 Homo sapiens
Suv39h2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of SUV39H1 declines with age in hematopoietic stem cells down
Homo sapiens SUV39H2 is overexpressed in many cancer tissues, such as leukemia, lymphomas, lung cancer, breast cancer, colorectal cancer, gastric cancer and hepatocellular cancer up

General Information

General Information Comment Organism
malfunction dysregulation of SUV39H1 is observed in different cancers Homo sapiens
physiological function the enzyme has roles in the brain during early neurodevelopment. Important roles in the maintenance of heterochromatin and gene repression. The enzyme is connected to cancer, having oncogenic or tumor-suppressive roles depending on the tumor type Homo sapiens
physiological function important roles in the maintenance of heterochromatin and gene repression. The enzyme is connected to cancer, having oncogenic or tumor-suppressive roles depending on the tumor type. SUV39H1-mediated H3K9 trimethylation regulates the expression of several genes Homo sapiens