Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.355 extracted from

  • Guerra, M.V.; Caceres, M.I.; Herrera-Soto, A.; Arredondo, S.B.; Varas-Godoy, M.; van Zundert, B.; Varela-Nallar, L.
    H3K9 Methyltransferases Suv39h1 and Suv39h2 control the differentiation of neural progenitor cells in the adult hippocampus (2021), Front. Cell Dev. Biol., 9, 778345.
    View publication on PubMed
Search for more literature for 2.1.1.355

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Mus musculus
-
 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O54864
-
-
Mus musculus Q9EQQ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dentate gyrus
-
 Mus musculus
-
hippocampus adult hippocampal progenitor cell Mus musculus
-
hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Mus musculus 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
H3K9 methyltransferase
-
 Mus musculus
H3K9 methyltransferase Suv39h1
-
 Mus musculus
H3K9 methyltransferase Suv39h2
-
 Mus musculus
SUV39H1
-
 Mus musculus
Suv39h2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus high levels of expression at early stages of neurogenesis and the expression decreased upon differentiation down
Mus musculus high levels of expression at early stages of neurogenesis and the expression decreased upon differentiation up

General Information

General Information Comment Organism
malfunction Suv39h1 and Suv39h2 knockdown in newborn cells of the adult mouse dentate gyrus by retrovirus-mediated RNA interference impairs neuronal differentiation of progenitor cells Mus musculus
physiological function during embryonic development, the repressive modification trimethylation of histone H3 on lysine 9 (H3K9me3) contributes to the cellular identity of different cell-types. H3K9me3 and H3K9 methyltransferases Suv39h1 and Suv39h2 are critically involved in the regulation of adult hippocampal neurogenesis by controlling the differentiation of neural progenitor cells Mus musculus
physiological function the enzyme controls the differentiation of neural progenitor cells during neurogenesis Mus musculus