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Literature summary for 2.1.1.355 extracted from

  • Lu, C.; Klement, J.D.; Yang, D.; Albers, T.; Lebedyeva, I.O.; Waller, J.L.; Liu, K.
    SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth (2020), Cancer Lett., 476, 87-96.
    View publication on PubMed
Search for more literature for 2.1.1.355

Inhibitors

Inhibitors Comment Organism Structure
F5446
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O43463
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon SUV39H1 expression is significantly up-regulated in human colorectal carcinoma as compared to normal colon Homo sapiens
-
colorectal cancer cell SUV39H1 expression is significantly up-regulated in human colorectal carcinoma as compared to normal colon Homo sapiens
-

Synonyms

Synonyms Comment Organism
SUV39H1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens SUV39H1 expression is significantly up-regulated in human colorectal carcinoma as compared to normal colon up

General Information

General Information Comment Organism
drug target pharmacological inhibition of SUV39H1 is an effective approach to suppress human colorectal carcinoma Homo sapiens
malfunction inhibition of SUV39H1 alters the expression of genes with known functions in DNA replication and cell cycle in the metastatic colon carcinoma cells, which is associated with cell cycle arrest at S phase in the metastatic human colon carcinoma cells, resulting in tumor cell apoptosis and growth inhibition in a concentration-dependent manner in vitro Homo sapiens