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Literature summary for 2.1.1.355 extracted from
- Diversity and functional specialization of H3K9-specific histone methyltransferases (2024), Bioessays, 46, e2300163.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| F449Y | mutation blocks the conversion of H3K9me2 into H3K9me3 | Schizosaccharomyces pombe |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Homo sapiens | activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? |  |
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Drosophila melanogaster | - |
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | P45975 | - |
- |
| Homo sapiens | O43463 | - |
- |
| Homo sapiens | Q9H5I1 | - |
- |
| Mus musculus | O54864 | - |
- |
| Mus musculus | Q9EQQ0 | - |
- |
| Neurospora crassa | Q8X225 | - |
- |
| Neurospora crassa DSM 1257 | Q8X225 | - |
- |
| Schizosaccharomyces pombe | O60016 | - |
- |
| Schizosaccharomyces pombe ATCC 24843 | O60016 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| ubiquitination | the Clr4 molecule contains many lysine residues that can be ubiquitinated. Without this modification at position K109, K110, K113, or K114, the enzyme can dimethylate but loses the ability to trimethylate H3K9 | Schizosaccharomyces pombe |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | - |
Drosophila melanogaster | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | activity toward histones in chromatin | Homo sapiens | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
| 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 | Su(var)3-9 is a di- and trimethyltransferase of H3K9 | Drosophila melanogaster | 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9 | - |
? | |
| additional information | Clr4 automethylates lysines K455 and K472 | Schizosaccharomyces pombe | ? | - |
- |
|
| additional information | the enzyme also methylates the non-histone substrates SET8 and DOT1L | Homo sapiens | ? | - |
- |
|
| additional information | SUV39H2 is capable of automethylation. The enzyme also methylates the non-histone substrates LSD1 and SUV39H2 | Homo sapiens | ? | - |
- |
|
| additional information | Clr4 automethylates lysines K455 and K472 | Schizosaccharomyces pombe ATCC 24843 | ? | - |
- |
|
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Clr4 | - |
Schizosaccharomyces pombe |
| Dim-5 | - |
Neurospora crassa |
| H3K9-specific histone methyltransferase | - |
Schizosaccharomyces pombe |
| H3K9-specific histone methyltransferase | - |
Neurospora crassa |
| H3K9-specific histone methyltransferase | - |
Homo sapiens |
| H3K9-specific histone methyltransferase | - |
Mus musculus |
| H3K9-specific histone methyltransferase | - |
Drosophila melanogaster |
| SU(VAR)3-9 | - |
Drosophila melanogaster |
| SUV39H1 | - |
Homo sapiens |
| SUV39H1 | - |
Mus musculus |
| Suv39h2 | - |
Homo sapiens |
| Suv39h2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | deletion of the clr4 gene eliminates H3K9me2/me3 but not H3K9me1, indicating the presence of another protein capable of monomethylating H3K9 | Schizosaccharomyces pombe |
| metabolism | SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H | Homo sapiens |
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