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Literature summary for 2.1.1.355 extracted from
- PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia (2022), Acta Pharm. Sin. B, 12, 1913-1927.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleolus | - |
Homo sapiens | 5730 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O43463 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow mononuclear cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SUV39H1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| drug target | HF6 recruits methyltransferase SUV39H1 to the nucleolar region in leukemia and provids a potential therapeutic target for PHF6-mutant leukemia | Homo sapiens |
| physiological function | PHF6 and SUV39H1 coordinately regulate cell proliferation in an interdependent manner. | Homo sapiens |
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