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Literature summary for 2.1.1.355 extracted from

  • Hachiya, R.; Shiihashi, T.; Shirakawa, I.; Iwasaki, Y.; Matsumura, Y.; Oishi, Y.; Nakayama, Y.; Miyamoto, Y.; Manabe, I.; Ochi, K.; Tanaka, M.; Goda, N.; Sakai, J.; Suganami, T.; Ogawa, Y.
    The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages (2016), Sci. Rep., 6, 28845 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.355

Organism

Organism UniProt Comment Textmining
Mus musculus Q96KQ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
-

Subunits

Subunits Comment Organism
? x * 180000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ESET
-
 Mus musculus
H3K9 methyltransferase
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 Mus musculus
SETDB1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction macrophage-specific enzyme-knockout mice exhibit higher serum interleukin-6 concentrations in response to lipopolysaccharide challenge and are more susceptible to endotoxin shock than wild type mice. Enzyme deficiency increases nuclear factor-kappaB p65 recruitment to the interleukin 6 promoter Mus musculus
physiological function the enzyme regulates toll-like receptor 4-mediated inflammatory responses in macrophages. The enzyme is an epigenetic regulator of proinflammatory cytokine expression in macrophages. The enzyme suppresses transcriptional activity of interleukin 6 promoter Mus musculus