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Literature summary for 2.1.1.355 extracted from

  • Ishimoto, K.; Kawamata, N.; Uchihara, Y.; Okubo, M.; Fujimoto, R.; Gotoh, E.; Kakinouchi, K.; Mizohata, E.; Hino, N.; Okada, Y.; Mochizuki, Y.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Inoue, T.; Tachibana, K.; Doi, T.
    Ubiquitination of lysine 867 of the human SETDB1 protein upregulates its histone H3 lysine 9 (H3K9) methyltransferase activity (2016), PLoS ONE, 11, e0165766 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15047
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
ubiquitination ubiquitination of lysine 867 of the human SETDB1 protein upregulates its histone H3 lysine 9 methyltransferase activity Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
glutathione Sepharose 4B column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
H3K9 methyltransferase
-
 Homo sapiens
SETDB1 SET domain, bifurcated 1 Homo sapiens