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Literature summary for 2.1.1.355 extracted from

  • Riahi, H.; Brekelmans, C.; Foriel, S.; Merkling, S.H.; Lyons, T.A.; Itskov, P.M.; Kleefstra, T.; Ribeiro, C.; van Rij, R.P.; Kramer, J.M.; Schenck, A.
    The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption (2019), PLoS Biol., 17, e2006146 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Drosophila melanogaster overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
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 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Drosophila melanogaster 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
G9a
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 Drosophila melanogaster
H3K9 methyltransferase
-
 Drosophila melanogaster

General Information

General Information Comment Organism
malfunction during oxidative stress exposure, enzyme mutants show overactivation of stress response genes, rapid depletion of glycogen, and inability to access lipid energy stores Drosophila melanogaster
physiological function the enzyme acts as a critical regulatory hub between the transcriptional and metabolic responses to oxidative stress Drosophila melanogaster