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Literature summary for 2.1.1.355 extracted from
- Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells (2018), Pharmacol. Res., 128, 252-263 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BIX-01294 | - |
Homo sapiens |  |
| chaetocin | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q96KQ7 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HMEC-1 cell | - |
Homo sapiens | - |
| microvascular endothelial cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G9a histone methyltransferase | - |
Homo sapiens |
| G9a HMT | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | enzyme inhibition attenuates the proliferation of HMEC-1 cells, nuclear localization of phosphorylated checkpoint kinase 1, and induces cell cycle arrest in G1 phase | Homo sapiens |
| physiological function | the enzyme plays a role in the promotion of endothelial cell proliferation | Homo sapiens |
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