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Literature summary for 2.1.1.355 extracted from

  • Xue, W.; Huang, J.; Chen, H.; Zhang, Y.; Zhu, X.; Li, J.; Zhang, W.; Yuan, Y.; Wang, Y.; Zheng, L.; Huang, K.
    Histone methyltransferase G9a modulates hepatic insulin signaling via regulating HMGA1 (2018), Biochim. Biophys. Acta, 1864, 338-346 .
    View publication on PubMed
Search for more literature for 2.1.1.355

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Homo sapiens overall reaction 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96KQ7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 overall reaction Homo sapiens 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9
-
 Homo sapiens S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
EHMT2
-
 Homo sapiens
G9a
-
 Homo sapiens
histone methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction in cultured hepatic cells, enzyme knockdown results in downregulation of insulin receptor, p-AKT and p-GSK3beta Homo sapiens
physiological function the enzyme modulates hepatic insulin signaling via regulating HMGA1 (high mobility group AT-hook 1, a key regulator responsible for the transcription of insulin receptor gene). In cultured hepatic cells, enzyme upregulation prevents the palmitic acid- or glucosamine-induced insulin resistance by preserving the normal level of insulin receptor and integrity of insulin signaling. Homo sapiens