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Literature summary for 2.1.1.355 extracted from

  • Eom, G.H.; Kim, K.; Kim, S.M.; Kee, H.J.; Kim, J.Y.; Jin, H.M.; Kim, J.R.; Kim, J.H.; Choe, N.; Kim, K.B.; Lee, J.; Kook, H.; Kim, N.; Seo, S.B.
    Histone methyltransferase PRDM8 regulates mouse testis steroidogenesis (2009), Biochem. Biophys. Res. Commun., 388, 131-136.
    View publication on PubMed
Search for more literature for 2.1.1.355

Cloned(Commentary)

Cloned (Comment) Organism
the 70 kDa full-length form is expressed in HEK-293T cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus the full-length of PRDM8 is localized exclusively in the nuclear region Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 the 30 kDa PRDM8 is most abundant in testis, heart, liver, and kidney, SDS-PAGE Mus musculus
70000
-
 the 70 kDa full-length PRDM8 is most abundant in brain and testis, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain PRDM8 of 70 kDa Mus musculus
-
heart PRDM8 of 30 kDa is expressed most prominently in cardiomyocytes from the heart Mus musculus
-
kidney PRDM8 of 30 kDa Mus musculus
-
liver PRDM8 of 70 kDa and of 30 kDa Mus musculus
-
additional information PRDM8 is not expressed in intestinal smooth muscles Mus musculus
-
oral epithelium
-
 Mus musculus
-
renal tubule
-
 Mus musculus
-
testis PRDM8 of 70 kDa Mus musculus
-
tongue PRDM8 is expressed most prominently in striated skeletal muscle from the tongue Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + histone H2A
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + histone H2B
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + histone H3(K9) PRDM8 specifically methylates H3(K9) of histones Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?
S-adenosyl-L-methionine + histone H4
-
 Mus musculus S-adenosyl-L-homocysteine + ?
-
 ?

Synonyms

Synonyms Comment Organism
histone methyltransferase
-
 Mus musculus
HMTase
-
 Mus musculus
PRDM8
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the expression of 70 kDa PRDM8 in brain and testis abruptly increases 3 weeks after birth up

General Information

General Information Comment Organism
physiological function PRDM8 repressed the expression of steroidogenic markers, p450c17c and luteinizing hormone receptor, which indicates its regulatory role in mouse testis development and steroidogenesis Mus musculus