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Literature summary for 2.1.1.355 extracted from

  • Chen, H.; Yan, Y.; Davidson, T.L.; Shinkai, Y.; Costa, M.
    Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells (2006), Cancer Res., 66, 9009-9016.
    View publication on PubMed
Search for more literature for 2.1.1.355

Activating Compound

Activating Compound Comment Organism Structure
deferoxamine increases G9a protein and activity in A549 cells, moreover, increases the methyltransferase activity of overexpressed GFP-hG9a fusion proteins Homo sapiens
dimethyloxalylglycine increases G9a protein and activity in A549 cells Homo sapiens
additional information hypoxia increases nuclear G9a protein by posttranslational mechanisms and its methyltransferase activity Homo sapiens

Application

Application Comment Organism
medicine G9a plays an important role in the hypoxia-induced dimethylated histone H3 lysine 9, which inhibits the expression of several genes that likely leads to solid tumor progression Mus musculus
medicine G9a plays an important role in the hypoxia-induced dimethylated histone H3 lysine 9, which inhibits the expression of several genes that likely leads to solid tumor progression Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information in G9a-/- embryonic stem cells, the increase in dimethylated histone H3 lysine 9 is significantly mitigated following hypoxia challenge Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
cyclohexamide decreases nuclear G9a protein but does not prevent its relative increase during hypoxic stress Homo sapiens
additional information hypoxia does not cause any measurable changes of G9a mRNA at earlier time intervals (1 and 3 hours) but leads to a significant decrease at 6 hours after challenge Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information G9a protein not detected in the cytoplasm Homo sapiens
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nucleus overexpressed exogenous G9a protein Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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 Homo sapiens
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embryo embryonic fibroblast cell Mus musculus
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embryonic stem cell
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 Mus musculus
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fibroblast embryonic fibroblast cell Mus musculus
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HEK-293 cell
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 Homo sapiens
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additional information MES cell and HIF-1alpha cell Mus musculus
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Synonyms

Synonyms Comment Organism
histone methyltransferase G9a
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 Mus musculus
histone methyltransferase G9a
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 Homo sapiens