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Literature summary for 2.1.1.355 extracted from

  • Tachibana, M.; Sugimoto, K.; Nozaki, M.; Ueda, J.; Ohta, T.; Ohki, M.; Fukuda, M.; Takeda, N.; Niida, H.; Kato, H.; Shinkai, Y.
    G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis (2002), Genes Dev., 16, 1779-1791.
    View publication on PubMed
Search for more literature for 2.1.1.355

Protein Variants

Protein Variants Comment Organism
additional information G9a deficient embryos, drastically decreased activity in vivo Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus histone methylation has significant effects on heterochromatin formation and transcriptional regulation ?
-
 ?
S-adenosyl-L-methionine + histone L-lysine Mus musculus Lys9 of histone 3 S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 G9a histone methyltransferase
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine H3-Lys9 methylation is catalyzed by the Suv39h family proteins Mus musculus
a

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Mus musculus
-
thymus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information histone methylation has significant effects on heterochromatin formation and transcriptional regulation Mus musculus ?
-
 ?
S-adenosyl-L-methionine + histone L-lysine Lys9 of histone H3 Mus musculus S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?
S-adenosyl-L-methionine + histone L-lysine Lys9 of histone 3 Mus musculus S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine
-
 ?