Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.1.1.355 extracted from

  • Shan, C.M.; Kim, J.K.; Wang, J.; Bao, K.; Sun, Y.; Chen, H.; Yue, J.X.; Stirpe, A.; Zhang, Z.; Lu, C.; Schalch, T.; Liti, G.; Nagy, P.L.; Tong, L.; Qiao, F.; Jia, S.
    The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin (2021), Cell Rep., 35, 109137.
    View publication on PubMed
Search for more literature for 2.1.1.355

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 Schizosaccharomyces pombe
-
 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9
-
 Schizosaccharomyces pombe 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine9
-
 ?

Synonyms

Synonyms Comment Organism
Clr4
-
 Schizosaccharomyces pombe
histone H3K9 methyltransferase
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
additional information the histone H3K9 methyltransferase Clr4 is mainly sequestered at pericentric repeats. This selective sequestration of Clr4 depends not only on H3K9M but also on H3K14 ubiquitylation (H3K14ub), a modification deposited by a Clr4-associated E3 ubiquitin ligase complex. In vitro, H3K14ub synergizes with H3K9M to interact with Clr4 and potentiates the inhibitory effects of H3K9M on Clr4 enzymatic activity Schizosaccharomyces pombe