Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8C3P7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
METTL3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | N6-methyladenosine (m6A) transferase METTL3 is as a regulator for terminating murine naive pluripotency. Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells are depleted for N6-methyladenosine in mRNAs, yet are viable. They fail to adequately terminate their naive state and undergo aberrant and restricted lineage priming at the postimplantation stage, which leads to early embryonic lethality. N6-methyladenosine predominantly and directly reduces mRNA stability | Mus musculus |