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Literature summary for 2.1.1.348 extracted from

  • Geula, S.; Moshitch-Moshkovitz, S.; Dominissini, D.; Mansour, A.; Kol, N.; Salmon-Divon, M.; Hershkovitz, V.; Peer, E.; Mor, N.; Manor, Y.; Ben-Haim, M.; Eyal, E.; Yunger, S.; Pinto, Y.; Jaitin, D.; Viukov, S.; Rais, Y.; Krupalnik, V.; Chomsky, E.; Zerbib, M.; Maza, I.; Rechavi, Y.; Massarwa, R.; Hanna, S.; Amit, I.; Levanon, E.Y.; Amariglio, N.; Stern-Ginossar, N.; Novershtern, N.; Rechavi, G.; Hanna, J.H.
    m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation (2015), Science, 347, 1002-1006 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C3P7
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Synonyms

Synonyms Comment Organism
METTL3
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Mus musculus

General Information

General Information Comment Organism
physiological function N6-methyladenosine (m6A) transferase METTL3 is as a regulator for terminating murine naive pluripotency. Mettl3 knockout preimplantation epiblasts and naive embryonic stem cells are depleted for N6-methyladenosine in mRNAs, yet are viable. They fail to adequately terminate their naive state and undergo aberrant and restricted lineage priming at the postimplantation stage, which leads to early embryonic lethality. N6-methyladenosine predominantly and directly reduces mRNA stability Mus musculus