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Literature summary for 2.1.1.348 extracted from

  • Lin, S.; Choe, J.; Du, P.; Triboulet, R.; Gregory, R.I.
    The m(6)A methyltransferase METTL3 promotes translation in human cancer cells (2016), Mol. Cell, 62, 335-345 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.348

Application

Application Comment Organism
medicine METTL3 expression is elevated in lung adenocarcinoma and promotes growth, survival, and invasion of human lung cancer cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D395A/A398A catalytically inactive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
 Homo sapiens 5840
-
ribosome METTL3 associates with ribosomes Homo sapiens 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA Homo sapiens
-
 S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86U44
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
H-1299 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
lung adenocarcinoma cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-
NCI-H1792 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + adenine in RNA
-
 Homo sapiens S-adenosyl-L-homocysteine + N6-methyladenine in RNA
-
 ?

Synonyms

Synonyms Comment Organism
METTL3
-
 Homo sapiens
RNA m6A methyltransferase
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function METTL3 associates with ribosomes and promotes translation in the cytoplasm. METTL3 depletion inhibits translation, and both wild-type and catalytically inactive METTL3 promote translation when tethered to a reporter mRNA. METTL3 enhances mRNA translation through an interaction with the translation initiation machinery Homo sapiens
physiological function the enzyme promotes translation of certain mRNAs including epidermal growth factor receptor and the Hippo pathway effector TAZ in human cancer cells. The enzyme enhances translation of target mRNAs by recruiting eIF3 to the translation initiation complex. The enzyme promotes growth, survival, and invasion of human lung cancer cells Homo sapiens