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Literature summary for 2.1.1.345 extracted from

  • Fricke, J.; Blei, F.; Hoffmeister, D.
    Enzymatic synthesis of psilocybin (2017), Angew. Chem. Int. Ed. Engl., 56, 12352-12355 .
    View publication on PubMed
Search for more literature for 2.1.1.345

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli KRX cells Psilocybe cubensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate Psilocybe cubensis
-
 2 S-adenosyl-L-homocysteine + psilocybin
-
 ?
S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate Psilocybe cubensis
-
 S-adenosyl-L-homocysteine + psilocybin
-
 ?
S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate Psilocybe cubensis
-
 S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Psilocybe cubensis P0DPA9
-
-

Purification (Commentary)

Purification (Comment) Organism
metal affinity column chromatography Psilocybe cubensis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate
-
 Psilocybe cubensis 2 S-adenosyl-L-homocysteine + psilocybin
-
 ?
S-adenosyl-L-methionine + 4-hydroxy-N-methyltryptamine 4-phosphate
-
 Psilocybe cubensis S-adenosyl-L-homocysteine + psilocybin
-
 ?
S-adenosyl-L-methionine + 4-hydroxytryptamine 4-phosphate
-
 Psilocybe cubensis S-adenosyl-L-homocysteine + 4-hydroxy-N-methyltryptamine 4-phosphate
-
 ?
S-adenosyl-L-methionine + baeocystin
-
 Psilocybe cubensis S-adenosyl-L-homocysteine + psilocybin
-
 ?
S-adenosyl-L-methionine + norbaeocystin
-
 Psilocybe cubensis S-adenosyl-L-homocysteine + baeocystin
-
 ?

Subunits

Subunits Comment Organism
? x * 34500, calculated from amino acid sequence Psilocybe cubensis

Synonyms

Synonyms Comment Organism
PsiM
-
 Psilocybe cubensis

General Information

General Information Comment Organism
metabolism the enzyme is involved in psilocybin synthesis Psilocybe cubensis