Literature summary for 2.1.1.34 extracted from

Hori, H.; Terui, Y.; Nakamoto, C.; Iwashita, C.; Ochi, A.; Watanabe, K.; Oshima, T.
Effects of polyamines from Thermus thermophilus, an extreme-thermophilic eubacterium, on tRNA methylation by tRNA (Gm18) methyltransferase (TrmH) (2016), J. Biochem., 159, 509-517 .

Search for more literature for 2.1.1.34

Activating Compound

Activating Compound	Comment	Organism	Structure
caldohexamine	1 mM caldohexamine increases TrmH activity at 60-80°C. No positive effect on the TrmH activity at 55°C	Thermus thermophilus
Polyamine	higher concentrations of linear polyamines inhibit TrmH activity at 55°C, while optimum concentration increases TrmH activity at 45-75°C	Thermus thermophilus
tetrakis(3-aminopropyl)ammonium	0.25 mM, increases TrmH activity at 40-85°C	Thermus thermophilus

Inhibitors

Inhibitors	Comment	Organism	Structure
Polyamine	higher concentrations of linear polyamines inhibit TrmH activity at 55°C, while optimum concentration increases TrmH activity at 45-75°C	Thermus thermophilus

Organism

Organism	UniProt	Comment	Textmining
Thermus thermophilus	Q5SM16	-	-
Thermus thermophilus DSM 579	Q5SM16	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + guanosine18 in tRNAPhe	substrate yeast tRNAPhe	Thermus thermophilus	S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe	-	?
S-adenosyl-L-methionine + guanosine18 in tRNAPhe	substrate yeast tRNAPhe	Thermus thermophilus DSM 579	S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe	-	?

Synonyms

Synonyms	Comment	Organism
TrmH	-	Thermus thermophilus

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Release 2023.1 (January 2023)