Literature summary for 2.1.1.320 extracted from

Quan, X.; Yue, W.; Luo, Y.; Cao, J.; Wang, H.; Wang, Y.; Lu, Z.
The protein arginine methyltransferase PRMT5 regulates Abeta-induced toxicity in human cells and Caenorhabditis elegans models of Alzheimers disease (2015), J. Neurochem., 134, 969-977.

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Application

Application	Comment	Organism
medicine	knockdown of isoform PRMT5 results in more paralysis in a Caenorhabditis elegans model of Alzheimer's disease	Caenorhabditis elegans

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	P46580	isoform PRMT5	-
Homo sapiens	O14744	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PRMT5	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	isoform PRMT5 is down-regulated by amyloid-beta in primary neurons and SH-SY5Y cells, and this is associated with the up-regulation of the PRMT5 target protein E2F-1. Knockdown of PRMT5 in SH-SY5Y cells over-expressing the Swedish mutant form of human amyloid-beta precursor protein causes activation of E2F-1/p53/Bax, NF-kappaB, and GSK-3beta pathways, which coincides with increased apoptosis. Co-depletion of E2F-1 reduces the activation of p53/Bax, NF-kappaB, and GSK-3beta, and limits cell apoptosis	Homo sapiens
physiological function	knockdown of isoform PRMT5 results in more paralysis in a Caenorhabditis elegans model of Alzheimer's disease	Caenorhabditis elegans

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Release 2023.1 (January 2023)