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Literature summary for 2.1.1.320 extracted from

  • Shilo, K.; Wu, X.; Sharma, S.; Welliver, M.; Duan, W.; Villalona-Calero, M.; Fukuoka, J.; Sif, S.; Baiocchi, R.; Hitchcock, C.L.; Zhao, W.; Otterson, G.A.
    Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors (2013), Diagn. Pathol., 8, 201.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine abundant expression of isoform PRMT5 and its symmetric methylation mark H4R3 in lung carcinoma but not in non-neoplastic human pulmonary alveolar and bronchial epithelial cell lines. More than two thirds of lung tumors express PRMT5. High levels of cytoplasmic PRMT5 are detected in 20.5% of non-small cell lung carcinomas and in 16.5% of pulmonary neuroendocrine tumors. High levels of nuclear PRMT5 are detected in 38.0% of non-small cell lung carcinomas and 24.0% of pulmonary neuroendocrine tumors. Cytoplasmic PRMT5 is associated with high grade in both non-small cell lung carcinomas and pulmonary pulmonary neuroendocrine tumors, while nuclear PRMT5 is more frequent in carcinoid tumors Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm high levels of cytoplasmic PRMT5 are detected in 20.5% of non-small cell lung carcinomas and in 16.5% of pulmonary neuroendocrine tumors Homo sapiens 5737
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nucleus high levels of nuclear PRMT5 are detected in 38.0% of non-small cell lung carcinomas and 24.0% of pulmonary neuroendocrine tumors Homo sapiens 5634
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Organism

Organism UniProt Comment Textmining
Homo sapiens O14744
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Source Tissue

Source Tissue Comment Organism Textmining
lung lung carcinoma Homo sapiens
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