Literature summary for 2.1.1.320 extracted from

Wang, Y.; Li, Q.; Liu, C.; Han, F.; Chen, M.; Zhang, L.; Cui, X.; Qin, Y.; Bao, S.; Gao, F.
Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development (2015), Biol. Reprod., 92, 104.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
gonad	isoform PRMT5 is abundantly expressed in the germ cells of both male and female gonads	Mus musculus	-

General Information

General Information	Comment	Organism
physiological function	deletion of Prmt5 results in germ cell depletion in adult mice. Germ cell loss is first observed between embryonic days 12.5 and 13.5, and very few of these cells remain at birth. Oct4, Sox2, and Nanog are abundantly expressed in Prmt5-deficient germ cells, whereas their expression is dramatically decreased in control germ cells. The expression of meiosis-associated genes is virtually absent in Prmt5-deficient female germ cells at embryonic day 13.5 , whereas the expression of other germ cell-specific genes is not changed. Methylation of histine H4R3 is completely absent after Prmt5 inactivation, whereas the level of histone H3R2 is not changed	Mus musculus

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Release 2023.1 (January 2023)