Cloned (Comment) | Organism |
---|---|
gene mts1, orf19.4831, cloning in Escherichia coli strain DH5alpha | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a mts1 disruptant mutant strain MTS105 that lacks (E,E)-9-methylsphinga-4,8-dienine in its glucosylceramides and contains (E)-sphing-4-enine and (E,E)-sphinga-4,8-dienine. Reintroducing the MTS1 gene into the mts1 disruptant restores the synthesis of (E,E)-9-methylsphinga-4,8-dienine in the glucosylceramides | Candida albicans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide | Candida albicans | - |
S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
gene mts1 | - |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide | - |
Candida albicans | S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C9-methyltransferase for sphingolipid 1 | - |
Candida albicans |
MTS1 | - |
Candida albicans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
malfunction | the Candida albicans mts1 disruptant had a decreased hyphal growth rate compared to the wild-type strain. The mts1 disruptant grows similarly to wild-type in medium containing SDS or fluconazole. The membrane structure of the mts1 disruptant is not disturbed, mutant phenotype, overview | Candida albicans |
physiological function | C9-methylated glucosylceramide is a fungus-specific sphingolipid. This lipid is a major membrane component in the cell and is thought to play important roles in the growth and virulence of several fungal species. The enzyme is involved in hyphal elongation. The C9-methyl group of a long-chain base in glucosylceramides plays an important role in the hyphal elongation of Candida albicans independent of lipid membrane disruption | Candida albicans |