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Literature summary for 2.1.1.317 extracted from

  • Oura, T.; Kajiwara, S.
    Candida albicans sphingolipid C9-methyltransferase is involved in hyphal elongation (2010), Microbiology, 156, 1234-1243.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene mts1, orf19.4831, cloning in Escherichia coli strain DH5alpha Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information construction of a mts1 disruptant mutant strain MTS105 that lacks (E,E)-9-methylsphinga-4,8-dienine in its glucosylceramides and contains (E)-sphing-4-enine and (E,E)-sphinga-4,8-dienine. Reintroducing the MTS1 gene into the mts1 disruptant restores the synthesis of (E,E)-9-methylsphinga-4,8-dienine in the glucosylceramides Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide Candida albicans
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S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide
-
?

Organism

Organism UniProt Comment Textmining
Candida albicans
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gene mts1
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + a (4E,8E)-sphinga-4,8-dienine ceramide
-
Candida albicans S-adenosyl-L-homocysteine + a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide
-
?

Synonyms

Synonyms Comment Organism
C9-methyltransferase for sphingolipid 1
-
Candida albicans
MTS1
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Candida albicans

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
Candida albicans

General Information

General Information Comment Organism
malfunction the Candida albicans mts1 disruptant had a decreased hyphal growth rate compared to the wild-type strain. The mts1 disruptant grows similarly to wild-type in medium containing SDS or fluconazole. The membrane structure of the mts1 disruptant is not disturbed, mutant phenotype, overview Candida albicans
physiological function C9-methylated glucosylceramide is a fungus-specific sphingolipid. This lipid is a major membrane component in the cell and is thought to play important roles in the growth and virulence of several fungal species. The enzyme is involved in hyphal elongation. The C9-methyl group of a long-chain base in glucosylceramides plays an important role in the hyphal elongation of Candida albicans independent of lipid membrane disruption Candida albicans