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Literature summary for 2.1.1.314 extracted from

  • Moehring, J.M.; Moehring, T.J.
    The post-translational trimethylation of diphthamide studied in vitro (1988), J. Biol. Chem., 263, 3840-3844.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
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Cricetulus griseus 5829
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Organism

Organism UniProt Comment Textmining
Cricetulus griseus
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-
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Saccharomyces cerevisiae
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-
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Source Tissue

Source Tissue Comment Organism Textmining
CHO-K1 cell
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Cricetulus griseus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] in the absence of ATP, S-adenosyl-L-methionine donates three methyl groups to form the trimethylamine and converts the intermediate intermediate to diphthine. The methyltransferase activity is specific for a single soluble cytosolic protein, translation elongation factor 2 Cricetulus griseus 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
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?
4 S-adenosyl-L-methionine + 2-[(3S)-3-carboxy-3-aminopropyl]-L-histidine-[translation elongation factor 2] in the absence of ATP, S-adenosyl-L-methionine donates three methyl groups to form the trimethylamine and converts the intermediate intermediate to diphthine. The methyltransferase activity is specific for a single soluble cytosolic protein, translation elongation factor 2 Cricetulus griseus CHO-K1 4 S-adenosyl-L-homocysteine + diphthine methyl ester-[translation elongation factor 2]
-
?