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Literature summary for 2.1.1.308 extracted from
- Biosynthesis of natural products with a P-C bond. Part 8: on the origin of the oxirane oxygen atom of fosfomycin in Streptomyces fradiae (1991), J. Chem. Soc. Perkin Trans., 1, 1993-1996.
No PubMed abstract available
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces fradiae | D2SNF5 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2-hydroxyethyl)phosphonate + S-adenosyl-L-methionine + methylcobalamin | when (R)- and (S)-2-hydroxyethylphosphonate are fed to Streptomyces fradiae producing fosfomycin, only (S)-2-hydroxyethylphosphonate is efficiently incorporated into fosfomycin (37% deuterium at C-1 of the aminophosphonic acid) | Streptomyces fradiae | (S)-2-hydroxypropylphosphonate + L-methionine + 5'-deoxyadenosine + cob(II)alamin | - |
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