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Literature summary for 2.1.1.307 extracted from

  • Patallo, E.P.; Blanco, G.; Fischer, C.; Brana, A.F.; Rohr, J.; Mendez, C.; Salas, J.A.
    Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes (2001), J. Biol. Chem., 276, 18765-18774.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces olivaceus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29043
-
x * 29043, calculated from sequence Streptomyces olivaceus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C Streptomyces olivaceus the enzyme is involved in the biosynthesis of the polyketide elloramycin S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C Streptomyces olivaceus Tü2353 the enzyme is involved in the biosynthesis of the polyketide elloramycin S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?

Organism

Organism UniProt Comment Textmining
Streptomyces olivaceus Q9AJU0
-
-
Streptomyces olivaceus Tü2353 Q9AJU0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-O-dimethyl-alpha-L-rhamnosyl)-tetracenomycin C the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus Tü2353 S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-O-trimethyl-alpha-L-rhamnosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-oleandrosyl-tetracenomycin C no activity with 8-demethyl-8-alpha-L-olivosyl tetracenomycin C or 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C Streptomyces olivaceus S-adenosyl-L-homocysteine + 8-demethyl-8-(4-O-methyl-alpha-L-oleandrosyl)-tetracenomycin C
-
?
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-oleandrosyl-tetracenomycin C no activity with 8-demethyl-8-alpha-L-olivosyl tetracenomycin C or 8-demethyl-8-alpha-L-rhamnosyl tetracenomycin C Streptomyces olivaceus Tü2353 S-adenosyl-L-homocysteine + 8-demethyl-8-(4-O-methyl-alpha-L-oleandrosyl)-tetracenomycin C
-
?

Subunits

Subunits Comment Organism
? x * 29043, calculated from sequence Streptomyces olivaceus

Synonyms

Synonyms Comment Organism
ElmMIII
-
Streptomyces olivaceus

General Information

General Information Comment Organism
physiological function the enzyme is involved in the biosynthesis of the polyketide elloramycin Streptomyces olivaceus