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Literature summary for 2.1.1.3 extracted from

  • Maw, G.A.
    Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver (1958), Biochem. J., 70, 168-173.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.1.1.3

Inhibitors

Inhibitors Comment Organism Structure
Ag2+
-
 Rattus norvegicus
Co2+
-
 Rattus norvegicus
Cu2+ 0.01 M, strong Rattus norvegicus
Fe2+
-
 Rattus norvegicus
glycine betaine 0.1 M Rattus norvegicus
Hg2+ 0.01 M, strong Rattus norvegicus
hydroxylamine 0.01 M Rattus norvegicus
K+
-
 Rattus norvegicus
Mn2+
-
 Rattus norvegicus
additional information no inhibition by dimethylthetin, sulfocholine (up to 0.1 M), mercaptoethanol, cysteine, Na2SO4, Li+, Cs+, Ca2+, Mg2+, NaN3, NaCN, NaF, EDTA, semicarbazide, iodoacetate Rattus norvegicus
phenylhydrazine 0.01 M Rattus norvegicus
Rb+
-
 Rattus norvegicus
Sodium mercaptoacetate
-
 Rattus norvegicus
Zn2+ 0.01 M, strong Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
additional information no activation by metal ions Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dimethylthetin + L-homocysteine Rattus norvegicus
-
 S-methylthioglycolate + L-methionine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine mechanism Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylthetin + L-homocysteine
-
 Rattus norvegicus S-methylthioglycolate + L-methionine
-
 ?
dimethylthetin + L-homocysteine i.e. dimethylsulfonioacetate, specific for L-homocysteine Rattus norvegicus S-methylthioglycolate + L-methionine i.e. methylthioacetate ?
additional information methyl group donors are ethylmethylthetin, dimethyl-alpha- and dimethyl-beta-propiothetin, ethylmethyl-beta-propiothetin, dimethyl-gamma-butyrothetin, methionine methylsulfonium, trimethylsulfonium, ethyldimethylsulfonium or butyldimethylsulfonium, no acceptors are cysteamine, 2-mercaptoethanol, DL-homocystine, sodium mercaptoacetate Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus