Application | Comment | Organism |
---|---|---|
additional information | a potent inhibitor of phenylethanolamine N-methyltransferase, which exhibits a minimal affinity for the alpha-adrenoceptor, would be a useful pharmacological tool for clearly defining the connection between central epinephrine concentrations and blood pressure. | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-fluoromethyl-7-(2,2,2-trifluoroethylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
3-fluoromethyl-7-(3,3,3-trifluoropropylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
3-fluoromethyl-7-(4,4,4-trifluorobutylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
3-fluoromethyl-7-(4-chlorobenzylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
3-fluoromethyl-7-propylsulfonyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
7-(3-methoxypropylsulfonyl)-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
7-butylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
7-ethylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | - |
Homo sapiens | |
additional information | the series of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines is more lipophilic but less potent than the correspnding sulfonamides. The interaction of the human phenylethanolamnie N-methyltransferase main chain carbonyl oxygen of Asn39 with the sulfonamide -NH- is likely responsible for much of the enhanced inhibitory potency of the sulfonamides versus the sulfones. | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11086 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0013 | - |
3-fluoromethyl-7-(3,3,3-trifluoropropylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.0014 | - |
3-fluoromethyl-7-(2,2,2-trifluoroethylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.0024 | - |
3-fluoromethyl-7-propylsulfonyl-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.014 | - |
7-ethylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determine using four concentrations of phenylethanolamnie as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.018 | - |
7-butylsulfonyl-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.032 | - |
3-fluoromethyl-7-(4-chlorobenzylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.067 | - |
3-fluoromethyl-7-(4,4,4-trifluorobutylsulfonyl)-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamine as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens | |
0.072 | - |
7-(3-methoxypropylsulfonyl)-3-fluoromethyl-1,2,3,4-tetrahydroisoquinoline | inhibition constants are determined using four concentrations of phenylethanolamnie as the variable substrate and three concentrations of inhibitor with a radiochemical assay. | Homo sapiens |