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Literature summary for 2.1.1.28 extracted from

  • Kvetnansky, R.; Kubovcakova, L.; Tillinger, A.; Micutkova, L.; Krizanova, O.; Sabban, E.L.
    Gene expression of phenylethanolamine N-methyltransferase in corticotropin-releasing hormone knockout mice during stress exposure (2006), Cell. Mol. Neurobiol., 26, 735-754.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Mus musculus
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male corticotropin-releasing hormone knockout mice (C57B1/129SV, 20-25 g, approximately 12 weeks old) and wild type mice
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Rattus norvegicus
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male Sprague-Dawley rats, 260-320 g, approximately 12 weeks old
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Source Tissue

Source Tissue Comment Organism Textmining
stellate ganglion higher levels of phenylethanolamine N-methyltransferase in stellate ganglia of mice compared with rats. Phenylethanolamine N-methyltransferase mRNA is present in stellate ganglia. Immobilization stress increases the gene expression of phenylethanolamine N-methyltransferase in stellate ganglia of rats, the highest levels of phenylethanolamine N-methyltransferase mRNA are immediatetly after and 3 h after the end of a stressful stimulus, while recovery to control levels occurs 6 h after the termination of immobilization. Immobilization repeated seven times further increases mRNA levels of phenylethanolamine N-methyltransferase in stellate ganglia of rats. There is no change in phenylethanol N-methyltransferase protein levels in stellate ganglia after a single immobilization, but protein levels are increased after repeated immobilization stress exposure. Rattus norvegicus
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stellate ganglion higher levels of phenylethanolamine N-methyltransferase in stellate ganglia of mice compared with rats. There are differences in noradrenaline and adrenaline concentration in stellate ganglia between wild type and knock out mice under basal and under stress conditons. Phenylethanolamine N-methyltransferase mRNA is present in stellate ganglia. There is an increase in phenylethanolamine N-methyltransferase mRNA levels in stellate ganglia of WT mice after exposure to single and also an increase in phenylethanolamine N-methyltransferase mRNA and protein levels after repeated immobilization compared with the unstressed control group. In corticotropin-releasing hormone knockout mice, no increase in phenylethanolamine N-methyltransferase gene expression and protein level occurs either after single or after repeated immobilization stress exposure. Mus musculus
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Synonyms

Synonyms Comment Organism
PNMT
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Mus musculus
PNMT
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Rattus norvegicus