Literature summary for 2.1.1.28 extracted from

Fuller, R.W.; Molloy, B.B.
Inhibition in vitro of norepinephrine N-methyltransferase by 2-aminotetralins, analogs of phenylethylamines with rigid conformation (1977), Biochem. Pharmacol., 26, 446-447.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-Aminotetralin	most effective inhibitor	Oryctolagus cuniculus
3,4-dichloroamphetamine	-	Oryctolagus cuniculus
5,6-Dichloro-2-aminotetralin	0.00093 mM, 50% inhibition, competitive with norepinephrine as substrate	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adrenal gland	-	Oryctolagus cuniculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
norepinephrine + S-adenosyl-L-methionine	-	Oryctolagus cuniculus	epinephrine + S-adenosyl-L-homocysteine	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00027	-	5,6-Dichloro-2-aminotetralin	-	Oryctolagus cuniculus

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Release 2023.1 (January 2023)