Cloned (Comment) | Organism |
---|---|
gene easF, a fragment of genomic DNA containing dmaW, easF, easE, and easC is amplified from the human-pathogenic, ergot alkaloid-producing fungus Aspergillus fumigatus and transformed into Aspergillus nidulans strain FGSC A767, a model fungus that does not contain any of the ergot alkaloid synthesis genes. Transformed Aspergillus nidulans strains produces chanoclavine-I and an earlier pathway intermediate | Aspergillus fumigatus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan | Aspergillus fumigatus | - |
S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Aspergillus fumigatus | Q4WZ60 | gene easF | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan | - |
Aspergillus fumigatus | S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine | - |
? | |
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan | easF encodes a methyltransferase that N-methylates DMAT to form the second intermediate, N-Me-DMAT | Aspergillus fumigatus | S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
S-adenosyl-L-methionine | - |
Aspergillus fumigatus |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the second step in the biosynthesis of ergot alkaloids, five steps of ergot alkaloid synthesis leading to the formation of chanoclavine-I, overview | Aspergillus fumigatus |