Literature summary for 2.1.1.261 extracted from

Ryan, K.L.; Moore, C.T.; Panaccione, D.G.
Partial reconstruction of the ergot alkaloid pathway by heterologous gene expression in Aspergillus nidulans (2013), Toxins, 5, 445-455.

Search for more literature for 2.1.1.261

Cloned(Commentary)

Cloned (Comment)	Organism
gene easF, a fragment of genomic DNA containing dmaW, easF, easE, and easC is amplified from the human-pathogenic, ergot alkaloid-producing fungus Aspergillus fumigatus and transformed into Aspergillus nidulans strain FGSC A767, a model fungus that does not contain any of the ergot alkaloid synthesis genes. Transformed Aspergillus nidulans strains produces chanoclavine-I and an earlier pathway intermediate	Aspergillus fumigatus

Cloned (Comment)

Organism

gene easF, a fragment of genomic DNA containing dmaW, easF, easE, and easC is amplified from the human-pathogenic, ergot alkaloid-producing fungus Aspergillus fumigatus and transformed into Aspergillus nidulans strain FGSC A767, a model fungus that does not contain any of the ergot alkaloid synthesis genes. Transformed Aspergillus nidulans strains produces chanoclavine-I and an earlier pathway intermediate

Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan	Aspergillus fumigatus	-	S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine	-	?

Organism

Organism	UniProt	Comment	Textmining
Aspergillus fumigatus	Q4WZ60	gene easF	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan	-	Aspergillus fumigatus	S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine	-	?
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan	easF encodes a methyltransferase that N-methylates DMAT to form the second intermediate, N-Me-DMAT	Aspergillus fumigatus	S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine	-	?

Cofactor

Cofactor	Comment	Organism	Structure
S-adenosyl-L-methionine	-	Aspergillus fumigatus

General Information

General Information	Comment	Organism
metabolism	the enzyme catalyzes the second step in the biosynthesis of ergot alkaloids, five steps of ergot alkaloid synthesis leading to the formation of chanoclavine-I, overview	Aspergillus fumigatus