BRENDA - Enzyme Database
show all sequences of 2.1.1.228

Targeting the bacterial epitranscriptome for antibiotic development discovery of novel tRNA-(N1G37) methyltransferase (TrmD) inhibitors

Zhong, W.; Koay, A.; Ngo, A.; Li, Y.; Nah, Q.; Wong, Y.H.; Chionh, Y.H.; Ng, H.Q.; Koh-Stenta, X.; Poulsen, A.; Foo, K.; McBee, M.; Choong, M.L.; El Sahili, A.; Kang, C.; Matter, A.; Lescar, J.; Hill, J.; Dedon, P.; ACS Infect. Dis. 5, 326-335 (2019) View publication on PubMed

Data extracted from this reference:

Application
Application
Commentary
Organism
drug development
bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. tRNA-(N1G37) methyltransferase (TrmD) is a target, which is conserved and essential in many bacterial pathogens
Pseudomonas aeruginosa
Cloned(Commentary)
Cloned (Commentary)
Organism
gene trmD, sequence comparisons
Pseudomonas aeruginosa
Inhibitors
Inhibitors
Commentary
Organism
Structure
(4-aminoquinazolin-2-yl)methyl 3-aminopyrazine-2-carboxylate
-
Pseudomonas aeruginosa
(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
1-(1H-pyrrol-2-yl)-2-[(thieno[2,3-d]pyrimidin-4-yl)oxy]ethan-1-one
-
Pseudomonas aeruginosa
1-(2-phenylpyrimidin-4-yl)-N-[(4-propoxyphenyl)methyl]piperidine-4-carboxamide
-
Pseudomonas aeruginosa
1-(3-chlorophenyl)-5-ethyl-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
-
Pseudomonas aeruginosa
1-[(2-chlorophenyl)methyl]-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
-
Pseudomonas aeruginosa
1-[7-(3,4-dimethylbenzoyl)-2H-[1,3]dioxolo[4,5-g]quinolin-8-yl]piperidine-4-carboxamide
-
Pseudomonas aeruginosa
2-(1H-inden-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
-
Pseudomonas aeruginosa
2-(5-chlorothiophen-2-yl)-2-oxoethyl (3,4-dimethoxyphenyl)acetate
-
Pseudomonas aeruginosa
2-(8-fluoro-3,4-dihydroquinolin-1(2H)-yl)-N-(quinolin-5-yl)acetamide
-
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 2-methylquinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 3-(cyclopropylsulfamoyl)thiophene-2-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-[(quinolin-5-yl)amino]ethyl 1-(5-carbamoylpyridin-2-yl)piperidine-4-carboxylate
-
Pseudomonas aeruginosa
2-phenyl-7-(quinoline-6-carbonyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one
-
Pseudomonas aeruginosa
2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoethyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate
-
Pseudomonas aeruginosa
2-[(4-acetylbenzene-1-sulfonyl)amino]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-[2-(1-methyl-2-phenyl-2,3-dihydro-1H-indol-3-yl)-2-oxoethyl]-1,3-dioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carbonitrile
-
Pseudomonas aeruginosa
2-[2-(3-chlorophenoxy)acetamido]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[2-(4-oxocinnolin-1(4H)-yl)acetamido]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[3-(benzenesulfonyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl]-N-methyl-N-phenylacetamide
-
Pseudomonas aeruginosa
2-[5-[2-(methylamino)-1,3-thiazol-4-yl]thiophen-2-yl]acetamide
-
Pseudomonas aeruginosa
3-(1H-pyrrol-1-yl)-N-[4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl]benzamide
-
Pseudomonas aeruginosa
3-(4-methoxyphenyl)-7-[(1H-pyrrol-2-yl)methyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
-
Pseudomonas aeruginosa
3-oxo-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
3-oxo-N-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
3-oxo-N-[[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
4-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]benzamide
-
Pseudomonas aeruginosa
4-[3-(8-hydroxyimidazo[1,2-a]pyridin-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl]benzene-1-sulfonamide
-
Pseudomonas aeruginosa
4-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]thiomorpholine
-
Pseudomonas aeruginosa
5,7-dimethyl-N-(4H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
-
Pseudomonas aeruginosa
5-(5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
-
Pseudomonas aeruginosa
5-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-2-(3-fluorophenyl)-7-methyl-3-(1H-pyrrol-1-yl)-2,3,3a,5-tetrahydro-4H-pyrazolo[3,4-d]pyridazin-4-one
-
Pseudomonas aeruginosa
6-(2-[[(furan-2-yl)methyl]amino]-1,3-thiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one
-
Pseudomonas aeruginosa
6-[5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl][1,2,4]triazolo[4,3-a]pyridine
-
Pseudomonas aeruginosa
ethyl 4-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]benzoate
-
Pseudomonas aeruginosa
additional information
high-throughput small-molecule library inhibitor screening, antibacterial growth inhibitory activities and haemolytic activity of selected TrmD inhibitors, binding affinity confirmed by thermal stability and surface plasmon resonance, overview
Pseudomonas aeruginosa
N-(2-methoxy-5-methylphenyl)-N'-[1,2,4]triazolo[4,3-a]pyridin-3-ylurea
-
Pseudomonas aeruginosa
N-(3,4-dimethylphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
-
Pseudomonas aeruginosa
N-(3-acetylphenyl)-N2-[5-chloro-2-(pyrrolidin-1-yl)phenyl]glycinamide
-
Pseudomonas aeruginosa
N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloropyridine-2-carboxamide
-
Pseudomonas aeruginosa
N-(3-carbamoylthiophen-2-yl)-2-(pyridin-4-yl)quinoline-4-carboxamide
-
Pseudomonas aeruginosa
N-(3-cyanothiophen-2-yl)-2-(furan-2-yl)quinoline-4-carboxamide
-
Pseudomonas aeruginosa
N-([1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-4-yl]methyl)-1H-indole-2-carboxamide
-
Pseudomonas aeruginosa
N-([2-[(morpholin-4-yl)methyl]phenyl]methyl)-2-(thiophene-2-carbonyl)benzamide
-
Pseudomonas aeruginosa
N-methyl-1-[2-([[2-(pyridin-3-yl)quinazolin-4-yl]amino]methyl)phenyl]methanesulfonamide
-
Pseudomonas aeruginosa
N-methyl-N-[(oxan-4-yl)methyl]-2-(thiophen-3-yl)acetamide
-
Pseudomonas aeruginosa
N-methyl-N-[[2-(pyrrolidin-1-yl)phenyl]methyl]-3-(1H-pyrrol-1-yl)benzamide
-
Pseudomonas aeruginosa
N-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]quinoline-6-carboxamide
-
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-1H-indole-2-carboxamide
-
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-2-(thiophen-2-yl)acetamide
-
Pseudomonas aeruginosa
N-[2-oxo-2-[(1,3,5-trimethyl-4,5-dihydro-1H-pyrazol-4-yl)amino]ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide
-
Pseudomonas aeruginosa
N-[3-(pyridin-4-yl)-1,2-oxazol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
-
Pseudomonas aeruginosa
N-[3-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]quinoline-2-carboxamide
-
Pseudomonas aeruginosa
N-[3-[(3-fluoro-4-methylphenyl)carbamoyl]phenyl]-1-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperidine-3-carboxamide
-
Pseudomonas aeruginosa
N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)propanamide
-
Pseudomonas aeruginosa
N-[4-chloro-3-(pyrrolidine-1-sulfonyl)phenyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
N-[[4-(piperidine-1-carbonyl)phenyl]methyl]-2-(thiophene-2-carbonyl)benzamide
-
Pseudomonas aeruginosa
sinefungin
-
Pseudomonas aeruginosa
suramin
-
Pseudomonas aeruginosa
[4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-2-yl][1-(4-methoxyphenyl)cyclohexyl]methanone
-
Pseudomonas aeruginosa
[5-(furan-2-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]methyl pyrazine-2-carboxylate
-
Pseudomonas aeruginosa
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0012
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
0.0018
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
S-adenosyl-L-methionine + guanine37 in tRNA
Pseudomonas aeruginosa
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNA
Pseudomonas aeruginosa UCBPP-PA14
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Pseudomonas aeruginosa
Q02RL6
-
-
Pseudomonas aeruginosa UCBPP-PA14
Q02RL6
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
TrmD luminescence assay development
755697
Pseudomonas aeruginosa
?
-
-
-
-
additional information
TrmD luminescence assay development
755697
Pseudomonas aeruginosa UCBPP-PA14
?
-
-
-
-
S-adenosyl-L-methionine + guanine37 in tRNA
-
755697
Pseudomonas aeruginosa
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNA
-
755697
Pseudomonas aeruginosa UCBPP-PA14
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNALeu(CAG)
-
755697
Pseudomonas aeruginosa
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNALeu(CAG)
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNALeu(CAG)
-
755697
Pseudomonas aeruginosa UCBPP-PA14
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNALeu(CAG)
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
PaTrmD
-
Pseudomonas aeruginosa
TrmD
-
Pseudomonas aeruginosa
tRNA-(N1G37) methyltransferase
-
Pseudomonas aeruginosa
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
thermostabilization of TrmD by compounds belonging to the pyridine-pyrazol-piperidin chemical cluster, overview
Pseudomonas aeruginosa
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0105
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
0.0113
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
Cofactor
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Pseudomonas aeruginosa
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-[(2-chlorophenyl)methyl]-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
0.00031
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-(1H-pyrrol-1-yl)-N-[4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl]benzamide
0.00049
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5-(5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
0.00053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0007
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoethyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate
0.00093
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-phenyl-7-(quinoline-6-carbonyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one
0.001
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[[4-(piperidine-1-carbonyl)phenyl]methyl]-2-(thiophene-2-carbonyl)benzamide
0.0011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(5-chlorothiophen-2-yl)-2-oxoethyl (3,4-dimethoxyphenyl)acetate
0.0013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-([1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-4-yl]methyl)-1H-indole-2-carboxamide
0.0013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-N-[[2-(pyrrolidin-1-yl)phenyl]methyl]-3-(1H-pyrrol-1-yl)benzamide
0.0014
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(1-methyl-2-phenyl-2,3-dihydro-1H-indol-3-yl)-2-oxoethyl]-1,3-dioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carbonitrile
0.0015
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0016
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloropyridine-2-carboxamide
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(3-chlorophenyl)-5-ethyl-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-(4-methoxyphenyl)-7-[(1H-pyrrol-2-yl)methyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(3-chlorophenoxy)acetamido]thiophene-3-carboxamide
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]benzamide
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)propanamide
0.002
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[5-[2-(methylamino)-1,3-thiazol-4-yl]thiophen-2-yl]acetamide
0.0021
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-cyanothiophen-2-yl)-2-(furan-2-yl)quinoline-4-carboxamide
0.0021
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]quinoline-2-carboxamide
0.0025
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(4-oxocinnolin-1(4H)-yl)acetamido]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
0.0025
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5,7-dimethyl-N-(4H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
0.0027
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[3-(benzenesulfonyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl]-N-methyl-N-phenylacetamide
0.0028
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(2-methoxy-5-methylphenyl)-N'-[1,2,4]triazolo[4,3-a]pyridin-3-ylurea
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(4-acetylbenzene-1-sulfonyl)amino]thiophene-3-carboxamide
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]thiomorpholine
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-1H-indole-2-carboxamide
0.0031
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[4-chloro-3-(pyrrolidine-1-sulfonyl)phenyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0034
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0034
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-[(quinolin-5-yl)amino]ethyl 1-(5-carbamoylpyridin-2-yl)piperidine-4-carboxylate
0.0036
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-2-(3-fluorophenyl)-7-methyl-3-(1H-pyrrol-1-yl)-2,3,3a,5-tetrahydro-4H-pyrazolo[3,4-d]pyridazin-4-one
0.0038
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(1H-inden-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
0.0039
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]quinoline-6-carboxamide
0.0043
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-1-[2-([[2-(pyridin-3-yl)quinazolin-4-yl]amino]methyl)phenyl]methanesulfonamide
0.0045
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 2-methylquinoline-4-carboxylate
0.0047
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-acetylphenyl)-N2-[5-chloro-2-(pyrrolidin-1-yl)phenyl]glycinamide
0.0049
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(1H-pyrrol-2-yl)-2-[(thieno[2,3-d]pyrimidin-4-yl)oxy]ethan-1-one
0.005
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3,4-dimethylphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
0.0053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 3-(cyclopropylsulfamoyl)thiophene-2-carboxylate
0.0053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
[5-(furan-2-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]methyl pyrazine-2-carboxylate
0.0054
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
6-[5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl][1,2,4]triazolo[4,3-a]pyridine
0.0056
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[3-(8-hydroxyimidazo[1,2-a]pyridin-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl]benzene-1-sulfonamide
0.0058
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-[7-(3,4-dimethylbenzoyl)-2H-[1,3]dioxolo[4,5-g]quinolin-8-yl]piperidine-4-carboxamide
0.0059
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
[4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-2-yl][1-(4-methoxyphenyl)cyclohexyl]methanone
0.006
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
ethyl 4-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]benzoate
0.006
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-carbamoylthiophen-2-yl)-2-(pyridin-4-yl)quinoline-4-carboxamide
0.0062
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-N-[(oxan-4-yl)methyl]-2-(thiophen-3-yl)acetamide
0.0066
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(8-fluoro-3,4-dihydroquinolin-1(2H)-yl)-N-(quinolin-5-yl)acetamide
0.0068
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[2-oxo-2-[(1,3,5-trimethyl-4,5-dihydro-1H-pyrazol-4-yl)amino]ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide
0.0083
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
sinefungin
0.0087
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0087
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-(pyridin-4-yl)-1,2-oxazol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
0.0091
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
suramin
0.0091
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0092
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
(4-aminoquinazolin-2-yl)methyl 3-aminopyrazine-2-carboxylate
0.0097
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-[[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.01
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-([2-[(morpholin-4-yl)methyl]phenyl]methyl)-2-(thiophene-2-carbonyl)benzamide
0.011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
6-(2-[[(furan-2-yl)methyl]amino]-1,3-thiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one
0.012
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-2-(thiophen-2-yl)acetamide
0.013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(2-phenylpyrimidin-4-yl)-N-[(4-propoxyphenyl)methyl]piperidine-4-carboxamide
0.014
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-[(3-fluoro-4-methylphenyl)carbamoyl]phenyl]-1-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperidine-3-carboxamide
Application (protein specific)
Application
Commentary
Organism
drug development
bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. tRNA-(N1G37) methyltransferase (TrmD) is a target, which is conserved and essential in many bacterial pathogens
Pseudomonas aeruginosa
Cloned(Commentary) (protein specific)
Commentary
Organism
gene trmD, sequence comparisons
Pseudomonas aeruginosa
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
S-adenosyl-L-methionine
-
Pseudomonas aeruginosa
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.00011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-[(2-chlorophenyl)methyl]-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
0.00031
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-(1H-pyrrol-1-yl)-N-[4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl]benzamide
0.00049
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5-(5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
0.00053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0007
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoethyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate
0.00093
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-phenyl-7-(quinoline-6-carbonyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one
0.001
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[[4-(piperidine-1-carbonyl)phenyl]methyl]-2-(thiophene-2-carbonyl)benzamide
0.0011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(5-chlorothiophen-2-yl)-2-oxoethyl (3,4-dimethoxyphenyl)acetate
0.0013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-([1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-4-yl]methyl)-1H-indole-2-carboxamide
0.0013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-N-[[2-(pyrrolidin-1-yl)phenyl]methyl]-3-(1H-pyrrol-1-yl)benzamide
0.0014
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(1-methyl-2-phenyl-2,3-dihydro-1H-indol-3-yl)-2-oxoethyl]-1,3-dioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carbonitrile
0.0015
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0016
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloropyridine-2-carboxamide
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(3-chlorophenyl)-5-ethyl-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
0.0017
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-(4-methoxyphenyl)-7-[(1H-pyrrol-2-yl)methyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(3-chlorophenoxy)acetamido]thiophene-3-carboxamide
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]benzamide
0.0019
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)propanamide
0.002
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[5-[2-(methylamino)-1,3-thiazol-4-yl]thiophen-2-yl]acetamide
0.0021
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-cyanothiophen-2-yl)-2-(furan-2-yl)quinoline-4-carboxamide
0.0021
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]quinoline-2-carboxamide
0.0025
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[2-(4-oxocinnolin-1(4H)-yl)acetamido]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
0.0025
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5,7-dimethyl-N-(4H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
0.0027
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[3-(benzenesulfonyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl]-N-methyl-N-phenylacetamide
0.0028
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(2-methoxy-5-methylphenyl)-N'-[1,2,4]triazolo[4,3-a]pyridin-3-ylurea
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-[(4-acetylbenzene-1-sulfonyl)amino]thiophene-3-carboxamide
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]thiomorpholine
0.0029
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-1H-indole-2-carboxamide
0.0031
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[4-chloro-3-(pyrrolidine-1-sulfonyl)phenyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0034
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
0.0034
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-[(quinolin-5-yl)amino]ethyl 1-(5-carbamoylpyridin-2-yl)piperidine-4-carboxylate
0.0036
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
5-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-2-(3-fluorophenyl)-7-methyl-3-(1H-pyrrol-1-yl)-2,3,3a,5-tetrahydro-4H-pyrazolo[3,4-d]pyridazin-4-one
0.0038
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(1H-inden-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
0.0039
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]quinoline-6-carboxamide
0.0043
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-1-[2-([[2-(pyridin-3-yl)quinazolin-4-yl]amino]methyl)phenyl]methanesulfonamide
0.0045
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 2-methylquinoline-4-carboxylate
0.0047
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-acetylphenyl)-N2-[5-chloro-2-(pyrrolidin-1-yl)phenyl]glycinamide
0.0049
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(1H-pyrrol-2-yl)-2-[(thieno[2,3-d]pyrimidin-4-yl)oxy]ethan-1-one
0.005
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3,4-dimethylphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
0.0053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 3-(cyclopropylsulfamoyl)thiophene-2-carboxylate
0.0053
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
[5-(furan-2-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]methyl pyrazine-2-carboxylate
0.0054
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
6-[5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl][1,2,4]triazolo[4,3-a]pyridine
0.0056
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
4-[3-(8-hydroxyimidazo[1,2-a]pyridin-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl]benzene-1-sulfonamide
0.0058
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-[7-(3,4-dimethylbenzoyl)-2H-[1,3]dioxolo[4,5-g]quinolin-8-yl]piperidine-4-carboxamide
0.0059
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
[4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-2-yl][1-(4-methoxyphenyl)cyclohexyl]methanone
0.006
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
ethyl 4-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]benzoate
0.006
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-(3-carbamoylthiophen-2-yl)-2-(pyridin-4-yl)quinoline-4-carboxamide
0.0062
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-methyl-N-[(oxan-4-yl)methyl]-2-(thiophen-3-yl)acetamide
0.0066
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
2-(8-fluoro-3,4-dihydroquinolin-1(2H)-yl)-N-(quinolin-5-yl)acetamide
0.0068
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[2-oxo-2-[(1,3,5-trimethyl-4,5-dihydro-1H-pyrazol-4-yl)amino]ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide
0.0083
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
sinefungin
0.0087
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0087
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-(pyridin-4-yl)-1,2-oxazol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
0.0091
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
suramin
0.0091
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.0092
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
(4-aminoquinazolin-2-yl)methyl 3-aminopyrazine-2-carboxylate
0.0097
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
3-oxo-N-[[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
0.01
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-([2-[(morpholin-4-yl)methyl]phenyl]methyl)-2-(thiophene-2-carbonyl)benzamide
0.011
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
6-(2-[[(furan-2-yl)methyl]amino]-1,3-thiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one
0.012
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-2-(thiophen-2-yl)acetamide
0.013
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
1-(2-phenylpyrimidin-4-yl)-N-[(4-propoxyphenyl)methyl]piperidine-4-carboxamide
0.014
-
pH and temperature not specified in the publication
Pseudomonas aeruginosa
N-[3-[(3-fluoro-4-methylphenyl)carbamoyl]phenyl]-1-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperidine-3-carboxamide
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
(4-aminoquinazolin-2-yl)methyl 3-aminopyrazine-2-carboxylate
-
Pseudomonas aeruginosa
(4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)methyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
1-(1H-pyrrol-2-yl)-2-[(thieno[2,3-d]pyrimidin-4-yl)oxy]ethan-1-one
-
Pseudomonas aeruginosa
1-(2-phenylpyrimidin-4-yl)-N-[(4-propoxyphenyl)methyl]piperidine-4-carboxamide
-
Pseudomonas aeruginosa
1-(3-chlorophenyl)-5-ethyl-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
-
Pseudomonas aeruginosa
1-[(2-chlorophenyl)methyl]-N-(4H-1,2,4-triazol-3-yl)-1H-pyrazole-4-carboxamide
-
Pseudomonas aeruginosa
1-[7-(3,4-dimethylbenzoyl)-2H-[1,3]dioxolo[4,5-g]quinolin-8-yl]piperidine-4-carboxamide
-
Pseudomonas aeruginosa
2-(1H-inden-2-yl)-5-[2-(1H-indol-3-yl)ethyl]-4-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
-
Pseudomonas aeruginosa
2-(5-chlorothiophen-2-yl)-2-oxoethyl (3,4-dimethoxyphenyl)acetate
-
Pseudomonas aeruginosa
2-(8-fluoro-3,4-dihydroquinolin-1(2H)-yl)-N-(quinolin-5-yl)acetamide
-
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 2-methylquinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)ethyl 3-(cyclopropylsulfamoyl)thiophene-2-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-(3-sulfamoylanilino)ethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-oxo-2-[(quinolin-5-yl)amino]ethyl 1-(5-carbamoylpyridin-2-yl)piperidine-4-carboxylate
-
Pseudomonas aeruginosa
2-phenyl-7-(quinoline-6-carbonyl)-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one
-
Pseudomonas aeruginosa
2-[(3,5-dichloropyridin-2-yl)amino]-2-oxoethyl 5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylate
-
Pseudomonas aeruginosa
2-[(4-acetylbenzene-1-sulfonyl)amino]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[(5-chloropyridin-2-yl)amino]-2-oxoethyl 2-(furan-2-yl)quinoline-4-carboxylate
-
Pseudomonas aeruginosa
2-[2-(1-methyl-2-phenyl-2,3-dihydro-1H-indol-3-yl)-2-oxoethyl]-1,3-dioxo-1,2,3,5,6,7-hexahydropyrrolo[1,2-c]pyrimidine-4-carbonitrile
-
Pseudomonas aeruginosa
2-[2-(3-chlorophenoxy)acetamido]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[2-(4-oxocinnolin-1(4H)-yl)acetamido]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
-
Pseudomonas aeruginosa
2-[3-(benzenesulfonyl)-7-methyl-4-oxo-1,8-naphthyridin-1(4H)-yl]-N-methyl-N-phenylacetamide
-
Pseudomonas aeruginosa
2-[5-[2-(methylamino)-1,3-thiazol-4-yl]thiophen-2-yl]acetamide
-
Pseudomonas aeruginosa
3-(1H-pyrrol-1-yl)-N-[4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl]benzamide
-
Pseudomonas aeruginosa
3-(4-methoxyphenyl)-7-[(1H-pyrrol-2-yl)methyl]-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine
-
Pseudomonas aeruginosa
3-oxo-N-(5,6,7,8-tetrahydronaphthalen-1-yl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
3-oxo-N-[1-[4-(1H-1,2,4-triazol-1-yl)phenyl]ethyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
3-oxo-N-[[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl]-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
4-[(tetrazolo[1,5-b]pyridazin-6-yl)amino]benzamide
-
Pseudomonas aeruginosa
4-[3-(8-hydroxyimidazo[1,2-a]pyridin-2-yl)-2,5-dimethyl-1H-pyrrol-1-yl]benzene-1-sulfonamide
-
Pseudomonas aeruginosa
4-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]thiomorpholine
-
Pseudomonas aeruginosa
5,7-dimethyl-N-(4H-1,2,4-triazol-3-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
-
Pseudomonas aeruginosa
5-(5-methylthiophen-2-yl)thieno[2,3-d]pyrimidin-4(3H)-one
-
Pseudomonas aeruginosa
5-[2-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-2-oxoethyl]-2-(3-fluorophenyl)-7-methyl-3-(1H-pyrrol-1-yl)-2,3,3a,5-tetrahydro-4H-pyrazolo[3,4-d]pyridazin-4-one
-
Pseudomonas aeruginosa
6-(2-[[(furan-2-yl)methyl]amino]-1,3-thiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one
-
Pseudomonas aeruginosa
6-[5-(thiophen-2-yl)-1,2,4-oxadiazol-3-yl][1,2,4]triazolo[4,3-a]pyridine
-
Pseudomonas aeruginosa
ethyl 4-[(3-cyano-6,7-dimethoxyquinolin-4-yl)amino]benzoate
-
Pseudomonas aeruginosa
additional information
high-throughput small-molecule library inhibitor screening, antibacterial growth inhibitory activities and haemolytic activity of selected TrmD inhibitors, binding affinity confirmed by thermal stability and surface plasmon resonance, overview
Pseudomonas aeruginosa
N-(2-methoxy-5-methylphenyl)-N'-[1,2,4]triazolo[4,3-a]pyridin-3-ylurea
-
Pseudomonas aeruginosa
N-(3,4-dimethylphenyl)-5,6-dihydro-4H-cyclopenta[d][1,2]oxazole-3-carboxamide
-
Pseudomonas aeruginosa
N-(3-acetylphenyl)-N2-[5-chloro-2-(pyrrolidin-1-yl)phenyl]glycinamide
-
Pseudomonas aeruginosa
N-(3-carbamoyl-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-4-chloropyridine-2-carboxamide
-
Pseudomonas aeruginosa
N-(3-carbamoylthiophen-2-yl)-2-(pyridin-4-yl)quinoline-4-carboxamide
-
Pseudomonas aeruginosa
N-(3-cyanothiophen-2-yl)-2-(furan-2-yl)quinoline-4-carboxamide
-
Pseudomonas aeruginosa
N-([1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-4-yl]methyl)-1H-indole-2-carboxamide
-
Pseudomonas aeruginosa
N-([2-[(morpholin-4-yl)methyl]phenyl]methyl)-2-(thiophene-2-carbonyl)benzamide
-
Pseudomonas aeruginosa
N-methyl-1-[2-([[2-(pyridin-3-yl)quinazolin-4-yl]amino]methyl)phenyl]methanesulfonamide
-
Pseudomonas aeruginosa
N-methyl-N-[(oxan-4-yl)methyl]-2-(thiophen-3-yl)acetamide
-
Pseudomonas aeruginosa
N-methyl-N-[[2-(pyrrolidin-1-yl)phenyl]methyl]-3-(1H-pyrrol-1-yl)benzamide
-
Pseudomonas aeruginosa
N-[(3,5-dimethyl-1,2-oxazol-4-yl)methyl]quinoline-6-carboxamide
-
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-1H-indole-2-carboxamide
-
Pseudomonas aeruginosa
N-[1-[3-(pyridin-4-yl)-1H-pyrazol-5-yl]piperidin-3-yl]-2-(thiophen-2-yl)acetamide
-
Pseudomonas aeruginosa
N-[2-oxo-2-[(1,3,5-trimethyl-4,5-dihydro-1H-pyrazol-4-yl)amino]ethyl]-5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxamide
-
Pseudomonas aeruginosa
N-[3-(pyridin-4-yl)-1,2-oxazol-5-yl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide
-
Pseudomonas aeruginosa
N-[3-([1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl]quinoline-2-carboxamide
-
Pseudomonas aeruginosa
N-[3-[(3-fluoro-4-methylphenyl)carbamoyl]phenyl]-1-([1,3]thiazolo[5,4-b]pyridin-2-yl)piperidine-3-carboxamide
-
Pseudomonas aeruginosa
N-[4-(2-amino-2-oxoethyl)-1,3-thiazol-2-yl]-3-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)propanamide
-
Pseudomonas aeruginosa
N-[4-chloro-3-(pyrrolidine-1-sulfonyl)phenyl]-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
-
Pseudomonas aeruginosa
N-[[4-(piperidine-1-carbonyl)phenyl]methyl]-2-(thiophene-2-carbonyl)benzamide
-
Pseudomonas aeruginosa
sinefungin
-
Pseudomonas aeruginosa
suramin
-
Pseudomonas aeruginosa
[4-(hydroxymethyl)-2,8-diazaspiro[4.5]decan-2-yl][1-(4-methoxyphenyl)cyclohexyl]methanone
-
Pseudomonas aeruginosa
[5-(furan-2-yl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl]methyl pyrazine-2-carboxylate
-
Pseudomonas aeruginosa
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0012
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
0.0018
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
S-adenosyl-L-methionine + guanine37 in tRNA
Pseudomonas aeruginosa
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNA
Pseudomonas aeruginosa UCBPP-PA14
-
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
?
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
TrmD luminescence assay development
755697
Pseudomonas aeruginosa
?
-
-
-
-
additional information
TrmD luminescence assay development
755697
Pseudomonas aeruginosa UCBPP-PA14
?
-
-
-
-
S-adenosyl-L-methionine + guanine37 in tRNA
-
755697
Pseudomonas aeruginosa
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNA
-
755697
Pseudomonas aeruginosa UCBPP-PA14
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNA
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNALeu(CAG)
-
755697
Pseudomonas aeruginosa
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNALeu(CAG)
-
-
-
?
S-adenosyl-L-methionine + guanine37 in tRNALeu(CAG)
-
755697
Pseudomonas aeruginosa UCBPP-PA14
S-adenosyl-L-homocysteine + N1-methylguanine37 in tRNALeu(CAG)
-
-
-
?
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
thermostabilization of TrmD by compounds belonging to the pyridine-pyrazol-piperidin chemical cluster, overview
Pseudomonas aeruginosa
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.0105
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
0.0113
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
General Information
General Information
Commentary
Organism
additional information
active site structure in complex with S-adenosyl-L-methionine, overview
Pseudomonas aeruginosa
General Information (protein specific)
General Information
Commentary
Organism
additional information
active site structure in complex with S-adenosyl-L-methionine, overview
Pseudomonas aeruginosa
KCat/KM [mM/s]
kcat/KM Value [1/mMs-1]
kcat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
5.83
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
9.44
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
KCat/KM [mM/s] (protein specific)
KCat/KM Value [1/mMs-1]
KCat/KM Value Maximum [1/mMs-1]
Substrate
Commentary
Organism
Structure
5.83
-
S-adenosyl-L-methionine
pH and temperature not specified in the publication
Pseudomonas aeruginosa
9.44
-
guanine37 in tRNALeu(CAG)
pH and temperature not specified in the publication
Pseudomonas aeruginosa
Other publictions for EC 2.1.1.228
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
755697
Zhong
Targeting the bacterial epitr ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14
ACS Infect. Dis.
5
326-335
2019
-
1
1
-
-
-
63
2
-
-
-
2
-
8
-
-
-
-
-
-
-
-
6
-
3
-
-
1
2
-
-
-
1
-
-
63
-
1
1
1
-
-
-
63
63
-
2
-
-
-
2
-
-
-
-
-
-
-
-
6
-
-
-
1
2
-
-
-
-
-
1
1
-
2
2
756152
Li
Backbone resonance assignment ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14
Biomol. NMR Assign.
13
327-332
2019
-
1
1
-
-
-
1
-
-
-
-
2
-
7
-
-
1
-
-
1
-
-
2
2
2
-
-
-
-
1
-
-
1
-
-
-
-
1
1
1
-
-
-
-
1
-
-
-
-
-
2
-
-
-
1
-
1
-
-
2
2
-
-
-
-
1
-
-
-
-
2
2
-
-
-
756153
Li
Backbone resonance assignment ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14
Biomol. NMR Assign.
13
49-53
2019
-
-
1
-
-
-
2
-
-
-
-
2
-
6
-
-
1
-
-
-
-
-
2
-
2
-
-
1
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
1
1
-
-
-
756774
Hou
Codon-specific translation by ...
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Saccharomyces cerevisiae, Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720, Saccharomyces cerevisiae ATCC 204508
Front. Genet.
10
713
2019
-
-
-
-
1
-
-
-
-
2
-
7
-
8
-
-
-
-
-
-
-
-
7
-
4
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
2
-
7
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
1
8
8
1
-
-
757408
Whitehouse
Development of inhibitors aga ...
Mycobacteroides abscessus
J. Med. Chem.
62
7210-7232
2019
-
1
1
1
-
-
50
-
-
-
-
1
-
6
-
-
1
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
1
-
-
-
50
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
757409
Zhong
Thienopyrimidinone derivative ...
Staphylococcus aureus, Mycobacterium tuberculosis, Pseudomonas aeruginosa
J. Med. Chem.
62
7788-7805
2019
-
-
3
2
-
3
42
3
-
2
-
3
-
5
-
-
-
-
-
-
-
-
3
-
12
1
-
-
-
1
-
-
3
-
-
26
-
-
3
3
2
-
3
26
42
-
3
-
2
-
3
-
-
-
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
3
3
-
-
-
757863
Jin
AtTrm5a catalyses 1-methylgua ...
Arabidopsis thaliana
Nucleic Acids Res.
47
883-898
2019
-
-
1
-
1
-
-
-
1
1
-
2
-
8
-
-
1
-
-
2
-
-
2
-
3
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
1
1
-
2
-
-
-
1
-
2
-
-
2
-
1
-
-
-
1
-
-
-
-
2
2
-
-
-
758329
Jaroensuk
Crystal structure and catalyt ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa UCBPP-PA14
RNA
25
1481-1496
2019
-
1
1
1
1
-
1
3
-
2
-
2
-
10
-
-
1
-
-
-
-
-
14
2
5
1
-
-
2
1
-
-
1
3
-
-
-
1
1
1
1
1
-
-
1
3
3
-
2
-
2
-
-
-
1
-
-
-
-
14
2
1
-
-
2
1
-
-
-
-
2
2
-
2
2
757201
Zhou
A hypertension-associated mit ...
Methanocaldococcus jannaschii, Methanocaldococcus jannaschii NBRC 100440, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii ATCC 43067, Methanocaldococcus jannaschii JAL-1, Methanocaldococcus jannaschii JCM 10045
J. Biol. Chem.
293
1425-1438
2018
-
-
-
-
1
-
-
-
-
-
-
6
-
17
-
-
-
-
-
-
-
-
12
-
5
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
12
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
755960
Wu
The crystal structure of the ...
Pyrococcus abyssi
Biochem. Biophys. Res. Commun.
493
240-245
2017
-
-
1
1
1
-
-
-
-
-
-
1
-
9
-
-
1
-
-
-
-
-
2
1
4
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
1
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
2
1
1
-
-
-
1
-
-
-
-
4
4
-
-
-
756161
Goto-Ito
Trm5 and TrmD two enzymes fr ...
Escherichia coli, Haemophilus influenzae, Methanocaldococcus jannaschii, Pyrococcus abyssi, Pyrococcus abyssi Orsay, Methanocaldococcus jannaschii NBRC 100440, Haemophilus influenzae RD, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii ATCC 43067, Methanocaldococcus jannaschii JAL-1, Haemophilus influenzae DSM 11121, Haemophilus influenzae KW20, Haemophilus influenzae ATCC 51907, Methanocaldococcus jannaschii JCM 10045
Biomolecules
7
32
2017
-
-
-
1
-
-
-
4
-
-
-
16
-
36
-
-
-
-
-
-
-
-
30
4
10
-
-
-
-
-
-
-
4
-
-
-
-
-
-
4
1
-
-
-
-
-
4
-
-
-
16
-
-
-
-
-
-
-
-
30
4
-
-
-
-
-
-
-
-
-
14
14
-
-
-
756163
Hori
Transfer RNA methyltransferas ...
Haemophilus influenzae, Aquifex aeolicus, Escherichia coli
Biomolecules
7
E23
2017
-
-
-
-
-
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
6
3
3
-
-
-
-
-
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
6
3
-
-
-
-
-
-
-
-
-
7
7
-
-
-
756631
Hou
TrmD A methyl transferase fo ...
Haemophilus influenzae, Aquifex aeolicus, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412, Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
Enzymes
41
89-115
2017
-
4
4
-
-
-
-
-
-
16
-
12
-
8
-
-
-
-
-
-
-
-
12
8
6
-
-
-
-
-
-
-
4
-
-
-
-
4
4
4
-
-
-
-
-
-
-
-
16
-
12
-
-
-
-
-
-
-
-
12
8
-
-
-
-
-
-
-
-
-
16
16
-
-
-
758348
Wang
Structural insight into the m ...
Methanocaldococcus jannaschii, Pyrococcus abyssi, Methanocaldococcus jannaschii DSM 2661
Sci. Adv.
3
e1700195
2017
-
-
1
2
7
-
-
-
-
2
-
4
-
6
-
-
1
-
-
-
-
-
7
1
6
2
-
-
-
2
-
-
2
-
-
-
-
-
1
2
2
7
-
-
-
-
-
-
2
-
4
-
-
-
1
-
-
-
-
7
1
2
-
-
-
2
-
-
-
-
4
4
-
-
-
757790
Christian
Methyl transfer by substrate ...
Haemophilus influenzae
Nat. Struct. Mol. Biol.
23
941-948
2016
-
1
-
-
-
-
1
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
2
1
2
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
4
4
-
-
-
758324
Urbonavicius
Evolution of tRNAPhe imG2 met ...
Nanoarchaeum equitans, Pyrococcus abyssi, Pyrococcus abyssi Orsay
RNA
22
1871-1883
2016
-
-
2
-
7
-
-
-
-
2
-
11
-
4
-
-
2
-
-
-
-
-
19
-
14
2
-
-
-
2
-
-
2
-
-
-
-
-
2
2
-
7
-
-
-
-
-
-
2
-
11
-
-
-
2
-
-
-
-
19
-
2
-
-
-
2
-
-
-
-
8
8
-
-
-
758376
Wang
Crystal structures of the bif ...
Pyrococcus abyssi
Sci. Rep.
6
33553
2016
-
-
1
1
2
-
-
-
-
1
-
2
-
9
-
-
1
-
-
-
-
-
3
2
5
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
1
2
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
3
2
-
-
-
-
-
-
-
-
-
4
4
-
-
-
735421
Powell
TRMT5 mutations cause a defect ...
Homo sapiens
Am. J. Hum. Genet.
97
319-328
2015
-
-
1
-
3
-
-
-
1
-
-
1
-
7
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
3
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
4
4
-
-
-
737174
Ito
Structural basis for methyl-do ...
Haemophilus influenzae, Thermotoga maritima, Haemophilus influenzae DSM 11121
Proc. Natl. Acad. Sci. USA
112
E4197-E4205
2015
-
-
-
2
-
-
-
12
-
-
-
3
-
4
-
-
-
2
-
-
-
-
17
2
2
-
-
-
10
1
-
-
2
-
-
-
-
-
-
2
2
-
-
-
-
-
12
-
-
-
3
-
-
-
-
-
-
-
-
17
2
-
-
-
10
1
-
-
-
-
4
4
-
10
10
757582
Hou
Kinetic analysis of tRNA meth ...
Escherichia coli, Haemophilus influenzae, Homo sapiens, Methanocaldococcus jannaschii, Methanocaldococcus jannaschii NBRC 100440, Haemophilus influenzae RD, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii ATCC 43067, Methanocaldococcus jannaschii JAL-1, Haemophilus influenzae DSM 11121, Haemophilus influenzae KW20, Haemophilus influenzae ATCC 51907, Methanocaldococcus jannaschii JCM 10045
Methods Enzymol.
560
91-116
2015
-
-
-
-
-
-
-
4
-
4
-
13
-
28
-
-
-
-
-
-
-
-
26
-
13
4
-
-
-
4
-
-
4
-
-
-
-
-
-
4
-
-
-
-
-
-
4
-
4
-
13
-
-
-
-
-
-
-
-
26
-
4
-
-
-
4
-
-
-
-
12
12
-
-
-
729858
Kawamura
Transfer RNA methyltransferase ...
Thermoplasma acidophilum, Thermoplasma acidophilum HO-62
Int. J. Mol. Sci.
16
91-113
2014
-
-
1
-
-
-
-
-
-
-
-
-
-
9
-
-
1
-
-
-
-
-
1
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
735927
Sakaguchi
A divalent metal ion-dependent ...
Escherichia coli
Chem. Biol.
21
1351-1360
2014
-
1
-
-
-
-
-
1
-
4
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1
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2
1
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Conservation of structure and ...
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737228
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The T. brucei TRM5 methyltrans ...
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721035
Sakaguchi
Recognition of guanosine by di ...
Escherichia coli, Methanocaldococcus jannaschii
RNA
18
1687-1701
2012
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2
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10
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2
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721029
Lahoud
Differentiating analogous tRNA ...
Escherichia coli, Methanocaldococcus jannaschii
RNA
17
1236-1246
2011
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24
2
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2
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2
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24
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Control of catalytic cycle by ...
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721026
Christian
Mechanism of N-methylation by ...
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16
2484-2492
2010
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1
18
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3
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18
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701123
Goto-Ito
Crystal structure of archaeal ...
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2008
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11
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1
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1
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1
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1
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1
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1
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1
1
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1
1
712103
Toyooka
Stabilization of tRNA (mG37) m ...
Aquifex aeolicus
Genes Cells
13
807-816
2008
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1
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687609
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Yeast mitochondrial initiator ...
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1
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1
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2
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Christian
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5
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2
2
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5
2
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5
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5
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5
2
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2
2
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5
5
673850
Takeda
The substrate specificity of t ...
Aquifex aeolicus
Genes Cells
11
1353-1365
2006
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1
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13
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6
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15
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3
1
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1
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1
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13
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1
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1
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15
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1
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711197
Christian
Catalysis by the second class ...
Methanocaldococcus jannaschii
Biochemistry
45
7463-7473
2006
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9
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11
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1
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1
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1
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2
1
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11
1
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9
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-
11
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1
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1
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1
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11
1
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1
1
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11
11
661154
Brule
Isolation and characterization ...
Escherichia coli, Homo sapiens
Biochemistry
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2004
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13
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20
2
4
2
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2
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1
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2
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5
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13
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3
2
2
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2
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20
2
2
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4
2
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662010
O'Dwyer
Characterization of Streptococ ...
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2004
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1
1
1
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2
2
1
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1
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2
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4
3
1
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1
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3
1
1
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2
1
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2
662622
Christian
Distinct origins of tRNA(m1G37 ...
Methanocaldococcus jannaschii
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2004
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1
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661585
Ahn
Crystal structure of tRNA(m1G3 ...
Haemophilus influenzae
EMBO J.
22
2593-2603
2003
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712737
Elkins
Insights into catalysis by a k ...
Escherichia coli
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931-949
2003
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1
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44
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44
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713482
Liu
Crystal structure of tRNA (m1G ...
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53
326-328
2003
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710708
Kim
Crystallization and preliminar ...
Haemophilus influenzae
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59
183-184
2002
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1
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1
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