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Literature summary for 2.1.1.224 extracted from

  • Wang, C.; Yang, X.; Wang, E.; Li, B.
    Quantum chemistry studies of adenosine 2503 methylation by S-adenosylmethionine-dependent enzymes (2013), Int. J. Quantum Chem., 113, 1409-1415.
No PubMed abstract available

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
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additional information energy profile and thermodynamics, overview Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin Staphylococcus aureus
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S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
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?
additional information Staphylococcus aureus methylation at C8 is similar to that at C2, cf. EC 2.1.1.192 ?
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?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus A5HBL2
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Reaction

Reaction Comment Organism Reaction ID
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [2Fe-2S] ferredoxin = S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [2Fe-2S] ferredoxin reaction mechanism modeling overview Staphylococcus aureus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin
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Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
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?
2 S-adenosyl-L-methionine + adenine2503 in 23S rRNA + 2 reduced [4Fe-4S] ferredoxin two S-adenosyl-L-methionine molecules serve as the cofactor by providing the 5'-deoxyadenosyl radical for substrate activation and the methyl Staphylococcus aureus S-adenosyl-L-homocysteine + L-methionine + 5'-deoxyadenosine + 8-methyladenine2503 in 23S rRNA + 2 oxidized [4Fe-4S] ferredoxin
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?
additional information methylation at C8 is similar to that at C2, cf. EC 2.1.1.192 Staphylococcus aureus ?
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?

Synonyms

Synonyms Comment Organism
Cfr
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Staphylococcus aureus

Cofactor

Cofactor Comment Organism Structure
Ferredoxin
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Staphylococcus aureus
S-adenosyl-L-methionine dependent on Staphylococcus aureus