Literature summary for 2.1.1.222 extracted from

Hsu, A.Y.; Poon, W.W.; Shepherd, J.A.; Myles, D.C.; Clarke, C.F.
Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis (1996), Biochemistry, 35, 9797-9806.

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Cloned(Commentary)

Cloned (Comment)	Organism
the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol	Escherichia coli	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)	S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine + 3-((2E,6E)-farnesyl)benzene-1,2-diol	i.e. 3-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzene-1,2-diol	Escherichia coli	S-adenosyl-L-homocysteine + 2-methoxy-6-((2E,6E)-farnesyl)phenol	i.e. 2-methoxy-6-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl)phenol	?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol	-	Escherichia coli	S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol	-	?
S-adenosyl-L-methionine + 3-(all-trans-octaprenyl)benzene-1,2-diol	the enzyme catalyzes two methylation steps in the biosynthesis of ubiquinone-8 in Escherichia coli, 1. the methylation of 3-(all-trans-octaprenyl)benzene-1,2-diol and 2. the methylation of 3-demethylubiquinol-8 (this reaction is classified as EC 2.1.1.64)	Escherichia coli	S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-octaprenyl)phenol	-	?

Synonyms

Synonyms	Comment	Organism
UbiG	-	Escherichia coli
UbiG methyltransferase	-	Escherichia coli

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Release 2023.1 (January 2023)