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Literature summary for 2.1.1.22 extracted from

  • Drozak, J.; Piecuch, M.; Poleszak, O.; Kozlowski, P.; Chrobok, L.; Baelde, H.J.; de Heer, E.
    UPF0586 protein C9orf41 homolog is anserine-producing methyltransferase (2015), J. Biol. Chem., 290, 17190-17205.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cell and HeLa cell Rattus norvegicus
expression in COS-7 cell and HeLa cell Homo sapiens
expression in COS-7 cell and HeLa cell Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
S-adenosyl-L-methionine pH 7.5, 30°C Gallus gallus
0.042
-
S-adenosyl-L-methionine pH 7.5, 30°C Rattus norvegicus
0.053
-
S-adenosyl-L-methionine pH 7.5, 30°C Homo sapiens
3.33
-
carnosine pH 7.5, 30°C Rattus norvegicus
4.96
-
carnosine pH 7.5, 30°C Homo sapiens
6.59
-
carnosine pH 7.5, 30°C Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Gallus gallus 5829
-
nucleus
-
Rattus norvegicus 5634
-
nucleus
-
Homo sapiens 5634
-
nucleus
-
Gallus gallus 5634
-

Organism

Organism UniProt Comment Textmining
Gallus gallus F1N9S8
-
-
Homo sapiens Q8N4J0
-
-
Rattus norvegicus Q5BJZ6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
muscle
-
Rattus norvegicus
-
muscle
-
Homo sapiens
-
muscle
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
Homo sapiens S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-His about 50% of the activity with carnosine ?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
Gallus gallus S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His about 50% of the activity with carnosine ?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
Rattus norvegicus S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His about 60% of the activity with carnosine ?
S-adenosyl-L-methionine + carnosine
-
Rattus norvegicus S-adenosyl-L-homocysteine + anserine
-
?
S-adenosyl-L-methionine + carnosine
-
Homo sapiens S-adenosyl-L-homocysteine + anserine
-
?
S-adenosyl-L-methionine + carnosine
-
Gallus gallus S-adenosyl-L-homocysteine + anserine
-
?
S-adenosyl-L-methionine + Gly-Gly-His similar activity as with carnosine Rattus norvegicus S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
?
S-adenosyl-L-methionine + Gly-Gly-His similar activity as with carnosine Homo sapiens S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
?
S-adenosyl-L-methionine + Gly-Gly-His similar activity as with carnosine Gallus gallus S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
?
S-adenosyl-L-methionine + Gly-His similar activity as with carnosine Rattus norvegicus S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
?
S-adenosyl-L-methionine + Gly-His similar activity as with carnosine Homo sapiens S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
?
S-adenosyl-L-methionine + Gly-His similar activity as with carnosine Gallus gallus S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
?

Synonyms

Synonyms Comment Organism
C9orf41
-
Homo sapiens
C9orf41
-
Gallus gallus
Carmt1
-
Rattus norvegicus
Carmt1
-
Homo sapiens
Carmt1
-
Gallus gallus
UPF0586 protein C9orf41 homolog
-
Rattus norvegicus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.002
-
carnosine pH 7.5, 30°C Homo sapiens
0.003
-
carnosine pH 7.5, 30°C Rattus norvegicus
0.003
-
carnosine pH 7.5, 30°C Gallus gallus
0.042
-
S-adenosyl-L-methionine pH 7.5, 30°C Gallus gallus
0.06
-
S-adenosyl-L-methionine pH 7.5, 30°C Homo sapiens
0.078
-
S-adenosyl-L-methionine pH 7.5, 30°C Rattus norvegicus

General Information

General Information Comment Organism
physiological function cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers Rattus norvegicus
physiological function cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers Homo sapiens
physiological function cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers Gallus gallus