BRENDA - Enzyme Database show
show all sequences of 2.1.1.22

UPF0586 protein C9orf41 homolog is anserine-producing methyltransferase

Drozak, J.; Piecuch, M.; Poleszak, O.; Kozlowski, P.; Chrobok, L.; Baelde, H.J.; de Heer, E.; J. Biol. Chem. 290, 17190-17205 (2015)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in COS-7 cell and HeLa cell
Gallus gallus
expression in COS-7 cell and HeLa cell
Homo sapiens
expression in COS-7 cell and HeLa cell
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.025
-
S-adenosyl-L-methionine
pH 7.5, 30C
Gallus gallus
0.042
-
S-adenosyl-L-methionine
pH 7.5, 30C
Rattus norvegicus
0.053
-
S-adenosyl-L-methionine
pH 7.5, 30C
Homo sapiens
3.33
-
carnosine
pH 7.5, 30C
Rattus norvegicus
4.96
-
carnosine
pH 7.5, 30C
Homo sapiens
6.59
-
carnosine
pH 7.5, 30C
Gallus gallus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Gallus gallus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
nucleus
-
Gallus gallus
5634
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Rattus norvegicus
5634
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
F1N9S8
-
-
Homo sapiens
Q8N4J0
-
-
Rattus norvegicus
Q5BJZ6
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
muscle
-
Gallus gallus
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Homo sapiens
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-His
about 50% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Gallus gallus
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His
about 50% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His
about 60% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Homo sapiens
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Homo sapiens
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Gallus gallus
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Homo sapiens
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Gallus gallus
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.002
-
carnosine
pH 7.5, 30C
Homo sapiens
0.003
-
carnosine
pH 7.5, 30C
Gallus gallus
0.003
-
carnosine
pH 7.5, 30C
Rattus norvegicus
0.042
-
S-adenosyl-L-methionine
pH 7.5, 30C
Gallus gallus
0.06
-
S-adenosyl-L-methionine
pH 7.5, 30C
Homo sapiens
0.078
-
S-adenosyl-L-methionine
pH 7.5, 30C
Rattus norvegicus
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in COS-7 cell and HeLa cell
Gallus gallus
expression in COS-7 cell and HeLa cell
Homo sapiens
expression in COS-7 cell and HeLa cell
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.025
-
S-adenosyl-L-methionine
pH 7.5, 30C
Gallus gallus
0.042
-
S-adenosyl-L-methionine
pH 7.5, 30C
Rattus norvegicus
0.053
-
S-adenosyl-L-methionine
pH 7.5, 30C
Homo sapiens
3.33
-
carnosine
pH 7.5, 30C
Rattus norvegicus
4.96
-
carnosine
pH 7.5, 30C
Homo sapiens
6.59
-
carnosine
pH 7.5, 30C
Gallus gallus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Gallus gallus
5829
-
cytosol
-
Homo sapiens
5829
-
cytosol
-
Rattus norvegicus
5829
-
nucleus
-
Gallus gallus
5634
-
nucleus
-
Homo sapiens
5634
-
nucleus
-
Rattus norvegicus
5634
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
muscle
-
Gallus gallus
-
muscle
-
Homo sapiens
-
muscle
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Homo sapiens
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-His
about 50% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Gallus gallus
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His
about 50% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + 3-aminobutanoyl-His
-
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + 3-aminobutanoyl-Ntau-methyl-L-His
about 60% of the activity with carnosine
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Homo sapiens
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + carnosine
-
734309
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Homo sapiens
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-Gly-His
similar activity as with carnosine
734309
Gallus gallus
S-adenosyl-L-homocysteine + Gly-Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Rattus norvegicus
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Homo sapiens
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
S-adenosyl-L-methionine + Gly-His
similar activity as with carnosine
734309
Gallus gallus
S-adenosyl-L-homocysteine + Gly-Ntau-methyl-L-His
-
-
-
?
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
0.002
-
carnosine
pH 7.5, 30C
Homo sapiens
0.003
-
carnosine
pH 7.5, 30C
Gallus gallus
0.003
-
carnosine
pH 7.5, 30C
Rattus norvegicus
0.042
-
S-adenosyl-L-methionine
pH 7.5, 30C
Gallus gallus
0.06
-
S-adenosyl-L-methionine
pH 7.5, 30C
Homo sapiens
0.078
-
S-adenosyl-L-methionine
pH 7.5, 30C
Rattus norvegicus
General Information
General Information
Commentary
Organism
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Gallus gallus
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Homo sapiens
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Gallus gallus
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Homo sapiens
physiological function
cotransfection of COS-7 cells with UPF0586 and carnosine synthase transforms the cells into efficient anserine producers
Rattus norvegicus
Other publictions for EC 2.1.1.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734309
Drozak
UPF0586 protein C9orf41 homolo ...
Gallus gallus, Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
17190-17205
2015
-
-
3
-
-
-
-
6
6
-
-
-
-
8
-
-
-
-
-
3
-
-
12
-
-
-
-
6
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
3
-
-
12
-
-
-
-
6
-
-
-
-
-
3
3
-
-
-
735092
Drozak
Molecular identification of ca ...
Gallus gallus
PLoS ONE
8
e64805
2013
-
-
1
-
-
-
-
1
-
-
3
-
-
3
-
-
-
-
-
1
-
-
2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
1
-
-
2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
485239
Raghavan
The use of alternative substra ...
Oryctolagus cuniculus
Eur. J. Biochem.
210
311-318
1992
-
-
-
-
-
-
-
1
-
-
1
2
-
4
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485238
McManus
-
Enzymatic synthesis of anserin ...
Cavia porcellus, Felis catus, Gallus gallus, Oryctolagus cuniculus, Rattus norvegicus
J. Biol. Chem.
237
1207-1211
1962
-
-
-
-
-
1
-
2
1
3
-
5
-
5
-
-
1
-
-
19
1
1
14
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
1
3
-
5
-
-
-
1
-
19
1
1
14
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-