BRENDA - Enzyme Database show
show all sequences of 2.1.1.22

Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine

McManus, R.; J. Biol. Chem. 237, 1207-1211 (1962)
No PubMed abstract available

Data extracted from this reference:

General Stability
General Stability
Organism
stable on freezing and thawing
Gallus gallus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
S-adenosyl-L-methionine
-
Gallus gallus
4
-
carnosine
-
Gallus gallus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Gallus gallus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Co2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Mn2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Zn2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + carnosine
Gallus gallus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
Cavia porcellus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
Rattus norvegicus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
Oryctolagus cuniculus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
Felis catus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Felis catus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Cavia porcellus
-
-
-
Felis catus
-
-
-
Gallus gallus
-
White Rock chick
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
partial
Gallus gallus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
low activity
Cavia porcellus
-
brain
low activity
Gallus gallus
-
brain
low activity
Rattus norvegicus
-
heart
low activity
Cavia porcellus
-
heart
low activity
Rattus norvegicus
-
kidney
much lower activity than in muscle
Cavia porcellus
-
kidney
much lower activity than in muscle
Felis catus
-
kidney
about the same activity as in muscle; much lower activity than in muscle
Gallus gallus
-
kidney
much lower activity than in muscle
Oryctolagus cuniculus
-
kidney
-
Rattus norvegicus
-
liver
same activity than in muscle
Gallus gallus
-
liver
20% of activity in muscle
Rattus norvegicus
-
lung
-
Cavia porcellus
-
lung
-
Rattus norvegicus
-
muscle
-
Cavia porcellus
-
muscle
-
Felis catus
-
muscle
-
Oryctolagus cuniculus
-
muscle
-
Gallus gallus
-
muscle
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0005
-
purified enzyme
Gallus gallus
Storage Stability
Storage Stability
Organism
-20°C, very stable
Gallus gallus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + carnosine
-
485238
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
485238
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + anserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
-
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
-
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + anserine
-
485238
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
-
485238
Felis catus
S-adenosyl-L-homocysteine + anserine
-
485238
Felis catus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
485238
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Cavia porcellus
S-adenosyl-L-homocysteine + anserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + anserine
-
485238
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Felis catus
S-adenosyl-L-homocysteine + anserine
-
485238
Felis catus
?
S-adenosyl-L-methionine + homocarnosine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + homoanserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + homocarnosine
-
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + homoanserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + L-histidine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + L-histidine
-
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
485238
Oryctolagus cuniculus
?
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
30% loss of activity when heated for 10 min in presence of carnosine, 70% loss of activity within 3 min in absence of carnosine; no loss of activity within 5 min in presence of carnosine
Gallus gallus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
-
Gallus gallus
pH Range
pH Minimum
pH Maximum
Commentary
Organism
6
9
-
Gallus gallus
General Stability (protein specific)
General Stability
Organism
stable on freezing and thawing
Gallus gallus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.09
-
S-adenosyl-L-methionine
-
Gallus gallus
4
-
carnosine
-
Gallus gallus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Gallus gallus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Co2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Mn2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Zn2+
inhibitory, reversible by addition of EDTA
Gallus gallus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
S-adenosyl-L-methionine + carnosine
Gallus gallus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
Cavia porcellus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
Rattus norvegicus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
Oryctolagus cuniculus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
Felis catus
biosynthesis of anserine
S-adenosyl-L-homocysteine + anserine
-
Felis catus
?
Purification (Commentary) (protein specific)
Commentary
Organism
partial
Gallus gallus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
low activity
Cavia porcellus
-
brain
low activity
Gallus gallus
-
brain
low activity
Rattus norvegicus
-
heart
low activity
Cavia porcellus
-
heart
low activity
Rattus norvegicus
-
kidney
much lower activity than in muscle
Cavia porcellus
-
kidney
much lower activity than in muscle
Felis catus
-
kidney
about the same activity as in muscle; much lower activity than in muscle
Gallus gallus
-
kidney
much lower activity than in muscle
Oryctolagus cuniculus
-
kidney
-
Rattus norvegicus
-
liver
same activity than in muscle
Gallus gallus
-
liver
20% of activity in muscle
Rattus norvegicus
-
lung
-
Cavia porcellus
-
lung
-
Rattus norvegicus
-
muscle
-
Cavia porcellus
-
muscle
-
Felis catus
-
muscle
-
Gallus gallus
-
muscle
-
Rattus norvegicus
-
muscle
-
Oryctolagus cuniculus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0005
-
purified enzyme
Gallus gallus
Storage Stability (protein specific)
Storage Stability
Organism
-20°C, very stable
Gallus gallus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
S-adenosyl-L-methionine + carnosine
-
485238
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
485238
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + anserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
-
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
-
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + anserine
-
485238
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
-
485238
Felis catus
S-adenosyl-L-homocysteine + anserine
-
485238
Felis catus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Gallus gallus
S-adenosyl-L-homocysteine + anserine
-
485238
Gallus gallus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Cavia porcellus
S-adenosyl-L-homocysteine + anserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + anserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + anserine
-
485238
Oryctolagus cuniculus
?
S-adenosyl-L-methionine + carnosine
biosynthesis of anserine
485238
Felis catus
S-adenosyl-L-homocysteine + anserine
-
485238
Felis catus
?
S-adenosyl-L-methionine + homocarnosine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + homoanserine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + homocarnosine
-
485238
Rattus norvegicus
S-adenosyl-L-homocysteine + homoanserine
-
485238
Rattus norvegicus
?
S-adenosyl-L-methionine + L-histidine
-
485238
Cavia porcellus
S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
485238
Cavia porcellus
?
S-adenosyl-L-methionine + L-histidine
-
485238
Oryctolagus cuniculus
S-adenosyl-L-homocysteine + Ntau-methyl-L-histidine
-
485238
Oryctolagus cuniculus
?
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
50
-
30% loss of activity when heated for 10 min in presence of carnosine, 70% loss of activity within 3 min in absence of carnosine; no loss of activity within 5 min in presence of carnosine
Gallus gallus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.5
-
Gallus gallus
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
6
9
-
Gallus gallus
Other publictions for EC 2.1.1.22
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
734309
Drozak
UPF0586 protein C9orf41 homolo ...
Gallus gallus, Homo sapiens, Rattus norvegicus
J. Biol. Chem.
290
17190-17205
2015
-
-
3
-
-
-
-
6
6
-
-
-
-
8
-
-
-
-
-
3
-
-
12
-
-
-
-
6
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
6
6
-
-
-
-
-
-
-
-
3
-
-
12
-
-
-
-
6
-
-
-
-
-
3
3
-
-
-
735092
Drozak
Molecular identification of ca ...
Gallus gallus
PLoS ONE
8
e64805
2013
-
-
1
-
-
-
-
1
-
-
3
-
-
3
-
-
-
-
-
1
-
-
2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
1
-
-
2
1
-
-
-
2
-
-
-
-
-
-
-
-
-
-
485239
Raghavan
The use of alternative substra ...
Oryctolagus cuniculus
Eur. J. Biochem.
210
311-318
1992
-
-
-
-
-
-
-
1
-
-
1
2
-
4
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
2
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
485238
McManus
-
Enzymatic synthesis of anserin ...
Cavia porcellus, Felis catus, Gallus gallus, Oryctolagus cuniculus, Rattus norvegicus
J. Biol. Chem.
237
1207-1211
1962
-
-
-
-
-
1
-
2
1
3
-
5
-
5
-
-
1
-
-
19
1
1
14
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
2
1
3
-
5
-
-
-
1
-
19
1
1
14
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-