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Literature summary for 2.1.1.212 extracted from

  • Xu, R.Y.; Nan, P.; Yang, Y.; Pan, H.; Zhou, T.; Chen, J.
    Ultraviolet irradiation induces accumulation of isoflavonoids and transcription of genes of enzymes involved in the calycosin-7-O-?-d-glucoside pathway in Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao (2011), Physiol. Plant., 142, 265-273.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone Astragalus membranaceus
-
 S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Organism

Organism UniProt Comment Textmining
Astragalus membranaceus
-
 var. mongholicus, from Inner Mongolia Seeds Administration Station Inner Mongolia, China, and further cultivated in pots
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
 Astragalus membranaceus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 2,7,4'-trihydroxyisoflavanone
-
 Astragalus membranaceus S-adenosyl-L-homocysteine + 2,7-dihydroxy-4'-methoxyisoflavanone
-
 ?

Synonyms

Synonyms Comment Organism
2-hydroxyisoflavanone 4'-O-methyltransferase
-
 Astragalus membranaceus
HI4'OMT
-
 Astragalus membranaceus

Cofactor

Cofactor Comment Organism Structure
S-adenosyl-L-methionine
-
 Astragalus membranaceus

General Information

General Information Comment Organism
metabolism 2,7-dihydroxy-4'-O-methoxy-isoflavanone is converted to formononetin, calycosin and calycosin-7-O-beta-D-glucoside via a series of reactions in the calycosin-7-O-beta-D-glucoside pathway. The 2,7,4'-trihydroxyisoflavanone is probably more easily caught by 2-hydroxyisoflavanone 4'-O-methyltransferase and hence provides more precursors for formononetin than being converted to daidzein, overview Astragalus membranaceus